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Reviewed, UniProtKB/Swiss-Prot Q7X7E9 (DNLI4_ORYSJ)

Last modified June 16, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative DNA ligase 4
    EC=6.5.1.1
Alternative name(s):
    DNA ligase IV
    Polydeoxyribonucleotide synthase [ATP] 4
Gene names
Name: LIG4
Ordered Locus Names: Os04g0606450, LOC_Os04g51700
ORF Names: OSJNBa0035M09.8
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

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Protein attributes

Sequence length1322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactor

Magnesium By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ATP-dependent DNA ligase family.

Contains 2 BRCT domains.

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Ontologies

Keywords
   Biological processDNA damage
DNA recombination
DNA repair
DNA replication
   Cellular componentNucleus
   DomainRepeat
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLigase
Gene Ontology (GO)
   Biological processDNA recombination

Inferred from electronic annotation. Source: UniProtKB-KW

DNA repair

Inferred from electronic annotation. Source: UniProtKB-KW

DNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

DNA ligase (ATP) activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13221322Putative DNA ligase 4
PRO_0000247468

Regions

Domain686 – 76883BRCT 1
Domain825 – 935111BRCT 2

Sites

Active site2671N6-AMP-lysine intermediate By similarity
Metal binding3171Magnesium 1 Potential
Metal binding4971Magnesium 2 Potential
Binding site2651ATP By similarity
Binding site2721ATP By similarity
Binding site2871ATP By similarity
Binding site5021ATP By similarity
Binding site5131ATP By similarity
Binding site5191ATP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q7X7E9-1 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 110BF7B94DB62A67

FASTA1,322149,078
        10         20         30         40         50         60 
MAATVRFGLL VAMFQAMSRD RTAAKKRARL RALLDRAYGP GGRDDYFSAL RLVLPGLDRE 

        70         80         90        100        110        120 
RGSYGLKEAA LASVLVDALG IAKDSPDAVR LTNWRRGGGF RNAGNFALVA AEVLQRRQGM 

       130        140        150        160        170        180 
TSGGLTIKEV NDALDRLAAT ENSVCLESEK LLLILDRSEK ASILSSLIKK TNALEMKWLL 

       190        200        210        220        230        240 
MIILKDLKLG ISEKSVFHEF HPDAEDLFNV TCDLRLVCEK LNDRSQRHKR QDIEVGKAVR 

       250        260        270        280        290        300 
PQLSMRVNNA SSAWKKLHGK QVVAECKFDG DRIQIHKNGE EIHFFSRSFL DHSEYAPGMS 

       310        320        330        340        350        360 
KVIIENILVD RCILDGEMLV WDTVLNRFAE FGSNQEIAKA AKEGLETDRQ LCCILEWIAS 

       370        380        390        400        410        420 
YVLALCVNIL SCQDFFFSNK RESYVAFDIL YAGDTSVIHQ SLTERHEILQ KVVRPLKGHL 

       430        440        450        460        470        480 
EILVPTGGLN IHRPPDEPCW SILAHSLDDV EKFFKDTVDN RFFPTSPNTD ELSNLSISLM 

       490        500        510        520        530        540 
IQFRFSDYSI CYVLREEGII LKDLESKWEP GDRSGKWLKL KPDYIHAGAD LDVIIIGGYY 

       550        560        570        580        590        600 
GSGRRGGEVA QFLVGLAVPS DDNSYPKRFL SFCRVGTGLS DEELDALVTK LKPHFRKNEY 

       610        620        630        640        650        660 
PKKPPRFYEV TNHSKERPDV WIESPDKQSV RFRKHLIYCI TKCRSVIISI TSDIRTIKSE 

       670        680        690        700        710        720 
VFAAPYSLRF PRIQRLRYDK PWHECLDVQA FVDIVHSSNG TTHRAADDDN DLKNVKNGGS 

       730        740        750        760        770        780 
FSMNLNDSVT HCIAAEKKAT RQGRIIHYSW ILDCCKEKRL LHLQPKFDPC LQPMHKFPEE 

       790        800        810        820        830        840 
IDSYADYFYW DIDISDLKQI FSNMDRAVVD SNMVHHYKKK YCADERFCFF QGCCVYFYHA 

       850        860        870        880        890        900 
PLVNADYNVI SDLALKRVKQ DLTMHGGQVC SILAPATHLI IVSVLQAYNF DMLYKSLPPA 

       910        920        930        940        950        960 
ERRYLHDKRL QVVSNKWLED SVEKQTRLPE TTYSLKPDTL EEIEIERSEE TVQPCNDKLE 

       970        980        990       1000       1010       1020 
ENEKADTSHV KHAPRKRGRP SSSASRTAKP APRPVRRTRA RRGNQHAKID DVEPEESDHG 

      1030       1040       1050       1060       1070       1080 
ETGLDDQIPD TDNISKMEVD SFDKDQVSAR PVRRTRARRG KQHAKIDYGQ SEESDPGETG 

      1090       1100       1110       1120       1130       1140 
QDDQRLDADY ISKMEEDSSD RDQGAHPTAP RVVRRSRAQR GKWLAKIDRE TGPGETGQDD 

      1150       1160       1170       1180       1190       1200 
KKLNADSISK MEEHAHDKDQ EPPPGAQLIT LDEQEPKGIK SSTTETPSSP KHERNQTVLR 

      1210       1220       1230       1240       1250       1260 
RDTAETTSSA TCEKMEQMVD PLHAMLLDMI PSLGQMKTDV GNRVAEAKAE TNPPWVGSST 

      1270       1280       1290       1300       1310       1320 
SSYVAPVPQA SASSASSSGV PAPHAGSSTQ STGVPAPDPT AGAPKKKKVS YKDVAGALLK 


DW

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References

[1]"Sequence and analysis of rice chromosome 4."
Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q., Zhang L. expand/collapse author list , Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y., Han B.
Nature 420:316-320(2002) [PubMed: 12447439] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"Oryza sativa full length cDNA."
The rice full-length cDNA consortium
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1068-1322.
Strain: cv. Nipponbare.

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Cross-references

Sequence databases

AL662968 Genomic DNA. Translation: CAD41778.2.
AK242148 mRNA. No translation available.
UniGeneOs.53597

3D structure databases

ModBaseSearch...

Organism-specific databases

GrameneQ7X7E9.

Family and domain databases

InterProIPR001357. BRCT.
IPR000977. DNA_ligase.
IPR012309. DNA_ligase_A_C.
IPR012310. DNA_ligase_A_M.
IPR016059. DNA_ligase_CS.
IPR012340. NA-bd_OB-fold.
[Graphical view]
Gene3DG3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 2 hits.
[Graphical view]
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50172. BRCT. 2 hits.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDNLI4_ORYSJ
AccessionPrimary (citable) accession number: Q7X7E9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: June 16, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents