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Q7X5L6

- RNPA_THEBO

UniProt

Q7X5L6 - RNPA_THEBO

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Protein
Ribonuclease P protein component
Gene
rnpA
Organism
Thermus brockianus
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme By similarity.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC
  2. tRNA binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein component (EC:3.1.26.5)
Short name:
RNase P protein
Short name:
RNaseP protein
Alternative name(s):
Protein C5
Gene namesi
Name:rnpA
OrganismiThermus brockianus
Taxonomic identifieri56956 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Ribonuclease P protein componentUniRule annotation
PRO_0000198553Add
BLAST

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7X5L6.

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P.
InterProiIPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view]
PfamiPF00825. Ribonuclease_P. 1 hit.
[Graphical view]
ProDomiPD003629. Ribonuclease_P. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiPS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7X5L6-1 [UniParc]FASTAAdd to Basket

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MDEKDLAAQP EEAGQDPRLP GPHEDPRRQE GAEAQAAEGP LAPHAQGERL    50
KRPPPAPGGK LVSLKGDRAF QRLRKGKAGR GRYVSVKWLP APELRVGIVV 100
SKKVGKAVVR NKVKRRLREI LRRLHLPKAH LLVVASPEAR EASYVELFQD 150
VARALKKSGL IQ 162
Length:162
Mass (Da):17,867
Last modified:October 1, 2003 - v1
Checksum:i4175E4CD315614C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY256337 Genomic DNA. Translation: AAO88967.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY256337 Genomic DNA. Translation: AAO88967.1 .

3D structure databases

ProteinModelPortali Q7X5L6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
HAMAPi MF_00227. RNase_P.
InterProi IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
[Graphical view ]
Pfami PF00825. Ribonuclease_P. 1 hit.
[Graphical view ]
ProDomi PD003629. Ribonuclease_P. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR00188. rnpA. 1 hit.
PROSITEi PS00648. RIBONUCLEASE_P. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains."
    Feltens R., Gossringer M., Willkomm D.K., Urlaub H., Hartmann R.K.
    Proc. Natl. Acad. Sci. U.S.A. 100:5724-5729(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCIB 12588 / YS38.

Entry informationi

Entry nameiRNPA_THEBO
AccessioniPrimary (citable) accession number: Q7X5L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The open reading frame (ORF) for this protein entirely encompasses the ORF for the 50S ribosomal protein L34 (rpmH). The two start codons are separated by four nucleotides.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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