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Protein

Ribonuclease P protein component

Gene

rnpA

Organism
Thermus brockianus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation

Miscellaneous

The open reading frame (ORF) for this protein entirely encompasses the ORF for the 50S ribosomal protein L34 (rpmH). The two start codons are separated by four nucleotides.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding
Biological processtRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)
Short name:
RNase P proteinUniRule annotation
Short name:
RNaseP proteinUniRule annotation
Alternative name(s):
Protein C5UniRule annotation
Gene namesi
Name:rnpAUniRule annotation
OrganismiThermus brockianus
Taxonomic identifieri56956 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001985531 – 162Ribonuclease P protein componentAdd BLAST162

Interactioni

Subunit structurei

Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7X5L6.
SMRiQ7X5L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RnpA family.UniRule annotation

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P. 1 hit.
InterProiView protein in InterPro
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
PANTHERiPTHR33992. PTHR33992. 1 hit.
PfamiView protein in Pfam
PF00825. Ribonuclease_P. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003629. Ribonuclease_P. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiView protein in PROSITE
PS00648. RIBONUCLEASE_P. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7X5L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKDLAAQP EEAGQDPRLP GPHEDPRRQE GAEAQAAEGP LAPHAQGERL
60 70 80 90 100
KRPPPAPGGK LVSLKGDRAF QRLRKGKAGR GRYVSVKWLP APELRVGIVV
110 120 130 140 150
SKKVGKAVVR NKVKRRLREI LRRLHLPKAH LLVVASPEAR EASYVELFQD
160
VARALKKSGL IQ
Length:162
Mass (Da):17,867
Last modified:October 1, 2003 - v1
Checksum:i4175E4CD315614C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY256337 Genomic DNA. Translation: AAO88967.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY256337 Genomic DNA. Translation: AAO88967.1.

3D structure databases

ProteinModelPortaliQ7X5L6.
SMRiQ7X5L6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_00227. RNase_P. 1 hit.
InterProiView protein in InterPro
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000100. RNase_P.
IPR020539. RNase_P_CS.
PANTHERiPTHR33992. PTHR33992. 1 hit.
PfamiView protein in Pfam
PF00825. Ribonuclease_P. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003629. Ribonuclease_P. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR00188. rnpA. 1 hit.
PROSITEiView protein in PROSITE
PS00648. RIBONUCLEASE_P. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRNPA_THEBO
AccessioniPrimary (citable) accession number: Q7X5L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2003
Last modified: March 15, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.