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Q7X3P1

- SPEB_PROMI

UniProt

Q7X3P1 - SPEB_PROMI

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Protein
Agmatinase
Gene
speB
Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine By similarity.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281Manganese By similarity
Metal bindingi151 – 1511Manganese By similarity
Metal bindingi153 – 1531Manganese By similarity
Metal bindingi155 – 1551Manganese By similarity
Metal bindingi232 – 2321Manganese By similarity
Metal bindingi234 – 2341Manganese By similarity

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
Agmatinase (EC:3.5.3.11)
Alternative name(s):
Agmatine ureohydrolase
Short name:
AUH
Gene namesi
Name:speB
OrganismiProteus mirabilis
Taxonomic identifieri584 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Pathology & Biotechi

Disruption phenotypei

Cells show a delay in differentiation to swarmer cells and are unable to migrate effectively on agar surfaces. Putrescine restores normal cell differentiation and migration ability.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306AgmatinaseUniRule annotation
PRO_0000173738Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7X3P1.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7X3P1-1 [UniParc]FASTAAdd to Basket

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MKNCTLGNET DNSLISNAFG FLRFPLNFQP YSSDADWVIT GVPFDMATSG    50
RAGTRHGPGA IRQISTNLAW EGHRWPWHFD MRERLKVVDC GDLVFNFGDA 100
QDMSDKLQAH TEKLLAAGKR CLTFGGDHFV TLPLLRAHAK HFGKMALVHF 150
DAHTDTYANG SKFDHGTMFY HAPNEGLIDP QHSVQIGIRT EHDTNNGFTV 200
LDAAQVNDRG VDDLVAQIKE IVGSLPVYLT FDIDCLDPAF APGTGTPVVG 250
GLTTDKALKM LRALQPLNIV GMDLVEVSPA YDQSDITALA GATIALDMLY 300
LQAAKK 306
Length:306
Mass (Da):33,473
Last modified:March 29, 2004 - v2
Checksum:iBFAD491A8881C77B
GO

Sequence cautioni

The sequence AAP55488.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY298901 Genomic DNA. Translation: AAP55488.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY298901 Genomic DNA. Translation: AAP55488.1 . Different initiation.

3D structure databases

ProteinModelPortali Q7X3P1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evidence that putrescine acts as an extracellular signal required for swarming in Proteus mirabilis."
    Sturgill G., Rather P.N.
    Mol. Microbiol. 51:437-446(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSPEB_PROMI
AccessioniPrimary (citable) accession number: Q7X3P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: February 19, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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