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Q7X3P1

- SPEB_PROMI

UniProt

Q7X3P1 - SPEB_PROMI

Protein

Agmatinase

Gene

speB

Organism
Proteus mirabilis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 2 (29 Mar 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of putrescine from agmatine.By similarity

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281ManganeseBy similarity
    Metal bindingi151 – 1511ManganeseBy similarity
    Metal bindingi153 – 1531ManganeseBy similarity
    Metal bindingi155 – 1551ManganeseBy similarity
    Metal bindingi232 – 2321ManganeseBy similarity
    Metal bindingi234 – 2341ManganeseBy similarity

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: InterPro

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Agmatinase (EC:3.5.3.11)
    Alternative name(s):
    Agmatine ureohydrolase
    Short name:
    AUH
    Gene namesi
    Name:speB
    OrganismiProteus mirabilis
    Taxonomic identifieri584 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

    Pathology & Biotechi

    Disruption phenotypei

    Cells show a delay in differentiation to swarmer cells and are unable to migrate effectively on agar surfaces. Putrescine restores normal cell differentiation and migration ability.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306AgmatinasePRO_0000173738Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7X3P1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.Curated

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    HAMAPiMF_01418. SpeB.
    InterProiIPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7X3P1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNCTLGNET DNSLISNAFG FLRFPLNFQP YSSDADWVIT GVPFDMATSG    50
    RAGTRHGPGA IRQISTNLAW EGHRWPWHFD MRERLKVVDC GDLVFNFGDA 100
    QDMSDKLQAH TEKLLAAGKR CLTFGGDHFV TLPLLRAHAK HFGKMALVHF 150
    DAHTDTYANG SKFDHGTMFY HAPNEGLIDP QHSVQIGIRT EHDTNNGFTV 200
    LDAAQVNDRG VDDLVAQIKE IVGSLPVYLT FDIDCLDPAF APGTGTPVVG 250
    GLTTDKALKM LRALQPLNIV GMDLVEVSPA YDQSDITALA GATIALDMLY 300
    LQAAKK 306
    Length:306
    Mass (Da):33,473
    Last modified:March 29, 2004 - v2
    Checksum:iBFAD491A8881C77B
    GO

    Sequence cautioni

    The sequence AAP55488.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY298901 Genomic DNA. Translation: AAP55488.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY298901 Genomic DNA. Translation: AAP55488.1 . Different initiation.

    3D structure databases

    ProteinModelPortali Q7X3P1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    HAMAPi MF_01418. SpeB.
    InterProi IPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence that putrescine acts as an extracellular signal required for swarming in Proteus mirabilis."
      Sturgill G., Rather P.N.
      Mol. Microbiol. 51:437-446(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSPEB_PROMI
    AccessioniPrimary (citable) accession number: Q7X3P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2004
    Last sequence update: March 29, 2004
    Last modified: October 1, 2014
    This is version 48 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3