Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7WZ28 (PGK_MYCH2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:mhp488
OrganismMycoplasma hyopneumoniae (strain 232) [Complete proteome] [HAMAP]
Taxonomic identifier295358 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145966

Regions

Nucleotide binding359 – 3624ATP By similarity
Region26 – 283Substrate binding By similarity
Region64 – 674Substrate binding By similarity

Sites

Binding site411Substrate By similarity
Binding site1241Substrate By similarity
Binding site1611Substrate By similarity
Binding site2121ATP By similarity
Binding site3011ATP; via carbonyl oxygen By similarity
Binding site3321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WZ28 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: CBE30FDFF43B0D7A

FASTA40444,223
        10         20         30         40         50         60 
MQPTYKNKKF IDDIDFLNKT VILRVDFNVP IKNGEISSIK RIIASLKTIK KIVNNGGKLV 

        70         80         90        100        110        120 
ILSHLGRIKS KEDLPKKSLR IVAEKLAEIL GQEIKFIPEN RGPKVENAIS QLEKGEILVL 

       130        140        150        160        170        180 
ENTRFQDLNN KAESKNDAEL GRYWASLGDV FINDAFGTLH RAHGSNVGIA TYIKESAIGY 

       190        200        210        220        230        240 
LVKEELDALS KLIFSPQRPF YAIIGGAKIS DKIGIISTLL EKADKVLIGG GMAYTFKKAL 

       250        260        270        280        290        300 
GYKIGLSIYE DDKLELAASL VKKYPDKLIL ALDAALAPEF ADLEPLYNQE NPLEIPDHLE 

       310        320        330        340        350        360 
GMDIGPLTIE LFKDHLKDGK TILWNGTLGV AEFKNFARGT KEVAKIIANL KECYSIIGGG 

       370        380        390        400 
DSIAAIEAEG LSNSFSHIST GGGASISFIE NGDLIGLGPI QEKD 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Mycoplasma hyopneumoniae."
Minion F.C., Wallace J., Lefkowitz E.J., Madsen M.L., Swartzell S., Cleary B.J., Mahairas G.G.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 232.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY319328 Genomic DNA. Translation: AAP82943.1.
AE017332 Genomic DNA. Translation: AAV27590.1.
RefSeqYP_115998.1. NC_006360.1.

3D structure databases

ProteinModelPortalQ7WZ28.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING295358.mhp488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV27590; AAV27590; mhp488.
GeneID3105374.
KEGGmhy:mhp488.
PATRIC20011651. VBIMycHyo77580_0529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMAAGHPVGK.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycMHYO295358:GH8B-513-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCH2
AccessionPrimary (citable) accession number: Q7WZ28
Secondary accession number(s): Q600G7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways