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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Mycoplasma hyopneumoniae (strain 232)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411SubstrateUniRule annotation
Binding sitei124 – 1241SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei212 – 2121ATPUniRule annotation
Binding sitei301 – 3011ATP; via carbonyl oxygenUniRule annotation
Binding sitei332 – 3321ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi359 – 3624ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMHYO295358:GH8B-513-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:mhp488
OrganismiMycoplasma hyopneumoniae (strain 232)
Taxonomic identifieri295358 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000006822 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Phosphoglycerate kinasePRO_0000145966Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7WZ28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 283Substrate bindingUniRule annotation
Regioni64 – 674Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WZ28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPTYKNKKF IDDIDFLNKT VILRVDFNVP IKNGEISSIK RIIASLKTIK
60 70 80 90 100
KIVNNGGKLV ILSHLGRIKS KEDLPKKSLR IVAEKLAEIL GQEIKFIPEN
110 120 130 140 150
RGPKVENAIS QLEKGEILVL ENTRFQDLNN KAESKNDAEL GRYWASLGDV
160 170 180 190 200
FINDAFGTLH RAHGSNVGIA TYIKESAIGY LVKEELDALS KLIFSPQRPF
210 220 230 240 250
YAIIGGAKIS DKIGIISTLL EKADKVLIGG GMAYTFKKAL GYKIGLSIYE
260 270 280 290 300
DDKLELAASL VKKYPDKLIL ALDAALAPEF ADLEPLYNQE NPLEIPDHLE
310 320 330 340 350
GMDIGPLTIE LFKDHLKDGK TILWNGTLGV AEFKNFARGT KEVAKIIANL
360 370 380 390 400
KECYSIIGGG DSIAAIEAEG LSNSFSHIST GGGASISFIE NGDLIGLGPI

QEKD
Length:404
Mass (Da):44,223
Last modified:October 1, 2003 - v1
Checksum:iCBE30FDFF43B0D7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319328 Genomic DNA. Translation: AAP82943.1.
AE017332 Genomic DNA. Translation: AAV27590.1.
RefSeqiWP_011206322.1. NC_006360.1.
YP_115998.1. NC_006360.1.

Genome annotation databases

EnsemblBacteriaiAAV27590; AAV27590; mhp488.
KEGGimhy:mhp488.
PATRICi20011651. VBIMycHyo77580_0529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY319328 Genomic DNA. Translation: AAP82943.1.
AE017332 Genomic DNA. Translation: AAV27590.1.
RefSeqiWP_011206322.1. NC_006360.1.
YP_115998.1. NC_006360.1.

3D structure databases

ProteinModelPortaliQ7WZ28.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV27590; AAV27590; mhp488.
KEGGimhy:mhp488.
PATRICi20011651. VBIMycHyo77580_0529.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciMHYO295358:GH8B-513-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Mycoplasma hyopneumoniae."
    Minion F.C., Wallace J., Lefkowitz E.J., Madsen M.L., Swartzell S., Cleary B.J., Mahairas G.G.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Mycoplasma hyopneumoniae strain 232, the agent of swine mycoplasmosis."
    Minion F.C., Lefkowitz E.J., Madsen M.L., Cleary B.J., Swartzell S.M., Mahairas G.G.
    J. Bacteriol. 186:7123-7133(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 232.

Entry informationi

Entry nameiPGK_MYCH2
AccessioniPrimary (citable) accession number: Q7WZ28
Secondary accession number(s): Q600G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.