Q7WVD3 (AQPZ_FLAJO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin Z

Gene names

Name:	aqpZ
Synonyms:	fjo22

Organism

Flavobacterium johnsoniae (Cytophaga johnsonae)

Taxonomic identifier

986 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	79 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity By similarity. HAMAP-Rule MF_01146
Subunit structure	Homotetramer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01146.
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›79	›79	Aquaporin Z HAMAP-Rule MF_01146		PRO_0000063988
Regions
	Transmembrane	4 – 26	23	Helical; Potential
	Transmembrane	31 – 53	23	Helical; Potential
	Motif	62 – 64	3	NPA 1 HAMAP-Rule MF_01146
Sites
	Site	19	1	Involved in tetramerization or stability of the tetramer By similarity
	Site	42	1	Selectivity filter By similarity
Experimental info
	Non-terminal residue	79	1

Sequences

	Sequence		Length	Mass (Da)
	Q7WVD3 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 7BB7B67806246ADC	FASTA	79	8,159
	10 20 30 40 50 60 MKKLFAEFFG TYWLVFGGCG SAVFAAGYPT LGIGFAGVAL AFGLTVLTMA YAVGHISGGH 70 FNPAVSFGLW AGGRFSAKD

References

[1]	"Cloning and characterization of the Flavobacterium johnsoniae gliding motility gene gldI." McBride M.J. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF527792 Genomic DNA. Translation: AAQ02336.1.
3D structure databases
ProteinModelPortal	Q7WVD3.
SMR	Q7WVD3. Positions 2-79.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
HAMAP	MF_01146. Aquaporin_Z.
InterPro	IPR023271. Aquaporin-like. IPR000425. MIP. IPR022357. MIP_CS. [Graphical view]
PANTHER	PTHR19139. PTHR19139. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PRINTS	PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
PROSITE	PS00221. MIP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AQPZ_FLAJO

Accession

Primary (citable) accession number: Q7WVD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	October 1, 2003
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program