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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Spiroplasma citri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk), Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Binding sitei223ATPUniRule annotation1
Binding sitei310ATP; via carbonyl oxygenUniRule annotation1
Binding sitei341ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi368 – 371ATPUniRule annotation4

GO - Molecular functioni

  • actin binding Source: CAFA
  • ATP binding Source: UniProtKB-KW
  • phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  • entry into host cell Source: CAFA
  • glycolytic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Protein family/group databases

MoonProtiQ7WTU1

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
OrganismiSpiroplasma citri
Taxonomic identifieri2133 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesSpiroplasmataceaeSpiroplasma

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460001 – 412Phosphoglycerate kinaseAdd BLAST412

Proteomic databases

PRIDEiQ7WTU1

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

  • actin binding Source: CAFA

Structurei

3D structure databases

ProteinModelPortaliQ7WTU1
SMRiQ7WTU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 24Substrate bindingUniRule annotation3
Regioni60 – 63Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WTU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKKELKDV QVKGKKVLVR VDFNVPMKDG QVTDDNRIIA ALPTIKYLIA
60 70 80 90 100
QEAKVILFSH LGKVKTADDL EKRDMAPVAK VLEQKLGQPV KFINAFEGKQ
110 120 130 140 150
LEEAINEMHN KEVILFQNTR FADIINSNGQ ISVDSEGKAA AKRESKNDSA
160 170 180 190 200
LGKYWASLGD VFVNDAFGTA HRAHASNVGI AENITESCLG FLVEKEVKML
210 220 230 240 250
SQCVDNPVKP FVAIIGGAKV SDKIGVIEHL LTKADKILIG GGMAYTFFAA
260 270 280 290 300
QGHKIGNSLL EVDKVEIAKT FLAKGQGKII LPIDALEAPE FADVPAKVTT
310 320 330 340 350
GFDIDDGYMG LDIGPKTIEL FKKELADAKT VTWNGPMGVF EFKNYSIGTK
360 370 380 390 400
AVCEAIAELK GAFTLIGGGD SAAAAIQLGY KDKFTHISTG GGASLEYMEG
410
KPLPGIEAVQ SK
Length:412
Mass (Da):44,388
Last modified:October 1, 2003 - v1
Checksum:i1F2C0787686A147F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580006 Genomic DNA Translation: CAE30465.1

Similar proteinsi

Entry informationi

Entry nameiPGK_SPICI
AccessioniPrimary (citable) accession number: Q7WTU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health