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Protein

Beta-galactosidase large subunit

Gene

lacL

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei468Proton donorBy similarity1
Active sitei536NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase large subunit (EC:3.2.1.23)
Short name:
Beta-gal large subunit
Alternative name(s):
Lactase large subunit
Gene namesi
Name:lacL
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576671 – 628Beta-galactosidase large subunitAdd BLAST628

Proteomic databases

PRIDEiQ7WTB4

Expressioni

Inductioni

By lactose.1 Publication

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7WTB4
SMRiQ7WTB4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WTB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQANINWLDN PEVFRVNQLP AHSDHPFFRD YREWQKQHSS YQQSLNGKWK
60 70 80 90 100
FHFSANPMDR PQDFYQRDFD SSNFDSIPVP SEIELSNYTQ NQYINVLFPW
110 120 130 140 150
EGKIFRRPAY ALDPNDHEEG SFSKGADNTV GSYLKRFDLS SALIGKDVHI
160 170 180 190 200
KFEGVEQAMY VWLNGHFVGY AEDSFTPSEF DLTPYIQDKD NLLAVEVFKH
210 220 230 240 250
STASWLEDQD MFRFSGIFRS VELLGIPATH LMDMDLKPRV ADNYQDGIFN
260 270 280 290 300
LKLHFIGKKA GSFHLLVKDI KGHTLLEKNE DIKENVQINN EKFENVHLWN
310 320 330 340 350
NHDPYLYQLL IEVYDEQQNL LELIPFQFGF RRIEISPEKV VLLNGKRLII
360 370 380 390 400
NGVNRHEWDA KRGRSITMSD MTTDINTFKE NNINAVRTCH YPNQIPWYYL
410 420 430 440 450
CDQNGIYVMA ENNLESHGTW QKMGEIEPSD NVPGSIPQWK EAVIDRARIN
460 470 480 490 500
YETFKNHTSI LFWSLGNESY AGDNIIAMNE FYKSHDDTRL VHYEGVVHRP
510 520 530 540 550
ELKDKISDVE SCMYLPPKKV EEYLQNDPPK PFMECEYMHD MGNSDGGMGS
560 570 580 590 600
YIKLLDKYPQ YFGGFIWDFI DQALLVHDEI SGHDVLRYGG DFDDRHSDYE
610 620
FSGDGLMFAD RTPKPAMQEV RYYYGLHK
Length:628
Mass (Da):73,479
Last modified:October 1, 2003 - v1
Checksum:iA4BBC9B78A84517A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512877 Genomic DNA Translation: CAD55499.1

Similar proteinsi

Entry informationi

Entry nameiBGAL_LACHE
AccessioniPrimary (citable) accession number: Q7WTB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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