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Q7WTB4

- BGAL_LACHE

UniProt

Q7WTB4 - BGAL_LACHE

Protein

Beta-galactosidase large subunit

Gene

lacL

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei468 – 4681Proton donorBy similarity
    Active sitei536 – 5361NucleophileBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH2. Glycoside Hydrolase Family 2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidase large subunit (EC:3.2.1.23)
    Short name:
    Beta-gal large subunit
    Alternative name(s):
    Lactase large subunit
    Gene namesi
    Name:lacL
    OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
    Taxonomic identifieri1587 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Beta-galactosidase large subunitPRO_0000057667Add
    BLAST

    Expressioni

    Inductioni

    By lactose.1 Publication

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7WTB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SUPFAMiSSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7WTB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQANINWLDN PEVFRVNQLP AHSDHPFFRD YREWQKQHSS YQQSLNGKWK    50
    FHFSANPMDR PQDFYQRDFD SSNFDSIPVP SEIELSNYTQ NQYINVLFPW 100
    EGKIFRRPAY ALDPNDHEEG SFSKGADNTV GSYLKRFDLS SALIGKDVHI 150
    KFEGVEQAMY VWLNGHFVGY AEDSFTPSEF DLTPYIQDKD NLLAVEVFKH 200
    STASWLEDQD MFRFSGIFRS VELLGIPATH LMDMDLKPRV ADNYQDGIFN 250
    LKLHFIGKKA GSFHLLVKDI KGHTLLEKNE DIKENVQINN EKFENVHLWN 300
    NHDPYLYQLL IEVYDEQQNL LELIPFQFGF RRIEISPEKV VLLNGKRLII 350
    NGVNRHEWDA KRGRSITMSD MTTDINTFKE NNINAVRTCH YPNQIPWYYL 400
    CDQNGIYVMA ENNLESHGTW QKMGEIEPSD NVPGSIPQWK EAVIDRARIN 450
    YETFKNHTSI LFWSLGNESY AGDNIIAMNE FYKSHDDTRL VHYEGVVHRP 500
    ELKDKISDVE SCMYLPPKKV EEYLQNDPPK PFMECEYMHD MGNSDGGMGS 550
    YIKLLDKYPQ YFGGFIWDFI DQALLVHDEI SGHDVLRYGG DFDDRHSDYE 600
    FSGDGLMFAD RTPKPAMQEV RYYYGLHK 628
    Length:628
    Mass (Da):73,479
    Last modified:October 1, 2003 - v1
    Checksum:iA4BBC9B78A84517A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512877 Genomic DNA. Translation: CAD55499.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ512877 Genomic DNA. Translation: CAD55499.1 .

    3D structure databases

    ProteinModelPortali Q7WTB4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH2. Glycoside Hydrolase Family 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SUPFAMi SSF49303. SSF49303. 1 hit.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Unusual organization for lactose and galactose gene clusters in Lactobacillus helveticus."
      Fortina M.G., Ricci G., Mora D., Guglielmetti S., Manachini P.L.
      Appl. Environ. Microbiol. 69:3238-3243(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
      Strain: ATCC 15009 / DSM 20075 / JCM 1120 / NBRC 15019 / NCIMB 11971 / Lh12.

    Entry informationi

    Entry nameiBGAL_LACHE
    AccessioniPrimary (citable) accession number: Q7WTB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3