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Q7WTB4 (BGAL_LACHE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-galactosidase large subunit

Short name=Beta-gal large subunit
EC=3.2.1.23
Alternative name(s):
Lactase large subunit
Gene names
Name:lacL
OrganismLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifier1587 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subunit structure

Heterodimer of a large and a small subunit By similarity.

Induction

By lactose. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Beta-galactosidase large subunit
PRO_0000057667

Sites

Active site4681Proton donor By similarity
Active site5361Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WTB4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: A4BBC9B78A84517A

FASTA62873,479
        10         20         30         40         50         60 
MQANINWLDN PEVFRVNQLP AHSDHPFFRD YREWQKQHSS YQQSLNGKWK FHFSANPMDR 

        70         80         90        100        110        120 
PQDFYQRDFD SSNFDSIPVP SEIELSNYTQ NQYINVLFPW EGKIFRRPAY ALDPNDHEEG 

       130        140        150        160        170        180 
SFSKGADNTV GSYLKRFDLS SALIGKDVHI KFEGVEQAMY VWLNGHFVGY AEDSFTPSEF 

       190        200        210        220        230        240 
DLTPYIQDKD NLLAVEVFKH STASWLEDQD MFRFSGIFRS VELLGIPATH LMDMDLKPRV 

       250        260        270        280        290        300 
ADNYQDGIFN LKLHFIGKKA GSFHLLVKDI KGHTLLEKNE DIKENVQINN EKFENVHLWN 

       310        320        330        340        350        360 
NHDPYLYQLL IEVYDEQQNL LELIPFQFGF RRIEISPEKV VLLNGKRLII NGVNRHEWDA 

       370        380        390        400        410        420 
KRGRSITMSD MTTDINTFKE NNINAVRTCH YPNQIPWYYL CDQNGIYVMA ENNLESHGTW 

       430        440        450        460        470        480 
QKMGEIEPSD NVPGSIPQWK EAVIDRARIN YETFKNHTSI LFWSLGNESY AGDNIIAMNE 

       490        500        510        520        530        540 
FYKSHDDTRL VHYEGVVHRP ELKDKISDVE SCMYLPPKKV EEYLQNDPPK PFMECEYMHD 

       550        560        570        580        590        600 
MGNSDGGMGS YIKLLDKYPQ YFGGFIWDFI DQALLVHDEI SGHDVLRYGG DFDDRHSDYE 

       610        620 
FSGDGLMFAD RTPKPAMQEV RYYYGLHK 

« Hide

References

[1]"Unusual organization for lactose and galactose gene clusters in Lactobacillus helveticus."
Fortina M.G., Ricci G., Mora D., Guglielmetti S., Manachini P.L.
Appl. Environ. Microbiol. 69:3238-3243(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
Strain: ATCC 15009 / DSM 20075 / JCM 1120 / NBRC 15019 / NCIMB 11971 / Lh12.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ512877 Genomic DNA. Translation: CAD55499.1.

3D structure databases

ProteinModelPortalQ7WTB4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.320. 1 hit.
3.20.20.80. 1 hit.
InterProIPR008979. Galactose-bd-like.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSPR00132. GLHYDRLASE2.
SUPFAMSSF49303. SSF49303. 1 hit.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL_LACHE
AccessionPrimary (citable) accession number: Q7WTB4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2003
Last modified: October 16, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries