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Protein

Beta-galactosidase small subunit

Gene

lacM

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase small subunit (EC:3.2.1.23)
Short name:
Beta-gal small subunit
Alternative name(s):
Lactase small subunit
Gene namesi
Name:lacM
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Beta-galactosidase small subunitPRO_0000057668Add
BLAST

Expressioni

Inductioni

By lactose.1 Publication

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7WTB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG651SX5.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
[Graphical view]
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WTB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYTNNQLHI IYGDATLGVN GKDFQYIFSY ERGGLESLKV HGKEWLYRVP
60 70 80 90 100
TPTFWRATTD NDRGSGFNLK AAQWLGADMF TKCTDIHLKV DRHDFAELPI
110 120 130 140 150
APFNNKFSNH EYAKSAEISF TYQTLTTPAT NAKIIYNIDD VGHIKVTMRY
160 170 180 190 200
YGKKGLPPLP VIGIRLIMPT AATGFDYEGL SGETYPDRMA GAKEGKFHID
210 220 230 240 250
GLPVTEYLVP QENGMHMQTK KLTINRETTQ NNVDRTNEKF SLSIQQAEKP
260 270 280 290 300
FNFSCLPYTA EELENATHIE ELPLVRRTVL VIAGAVRGVG GIDSWGTDVE
310
SAYHINPELD HEFSFILN
Length:318
Mass (Da):35,895
Last modified:September 30, 2003 - v1
Checksum:i0BDB79B71E6D58C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512877 Genomic DNA. Translation: CAD55500.1.
RefSeqiWP_003627057.1. NZ_JRTS01000136.1.

Genome annotation databases

PATRICi27424867. VBILacHel2059_1299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ512877 Genomic DNA. Translation: CAD55500.1.
RefSeqiWP_003627057.1. NZ_JRTS01000136.1.

3D structure databases

ProteinModelPortaliQ7WTB3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi27424867. VBILacHel2059_1299.

Phylogenomic databases

OrthoDBiEOG651SX5.

Family and domain databases

Gene3Di2.70.98.10. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR014718. Glyco_hydro-type_carb-bd_sub.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
[Graphical view]
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF74650. SSF74650. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Unusual organization for lactose and galactose gene clusters in Lactobacillus helveticus."
    Fortina M.G., Ricci G., Mora D., Guglielmetti S., Manachini P.L.
    Appl. Environ. Microbiol. 69:3238-3243(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TRANSCRIPTIONAL REGULATION.
    Strain: ATCC 15009 / DSM 20075 / JCM 1120 / NBRC 15019 / NCIMB 11971 / Lh12.

Entry informationi

Entry nameiBGAM_LACHE
AccessioniPrimary (citable) accession number: Q7WTB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2004
Last sequence update: September 30, 2003
Last modified: March 3, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.