Q7WRC7 (EFG1_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G 1
Short name=EF-G 1

Gene names

Name:	fusA1
Ordered Locus Names:	BB0026

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 700	700	Elongation factor G 1 HAMAP MF_00054_B		PRO_0000091078
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	88 – 92	5	GTP By similarity
	Nucleotide binding	142 – 145	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7WRC7 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 053E7A662EFCC51F	FASTA	700	77,088
	10 20 30 40 50 60 MARKTPIERY RNIGISAHID AGKTTTTERI LFYTGVNHKL GETHDGSATM DWMEQEQERG 70 80 90 100 110 120 ITITSAATTA FWRGMAGNYP EHRINIIDTP GHVDFTIEVE RSMRVLDGAC MVYCAVGGVQ 130 140 150 160 170 180 PQSETVWRQA NKYGVPRLAF VNKMDRTGAN FFKVYDQLKT RLRANPVPIV IPIGAEDSFT 190 200 210 220 230 240 GVVDLVKMKA IIWDEASQGT KFEYGDIPAE LEGTANEWRE KLVEAAAESS EELMNKYLET 250 260 270 280 290 300 GSLDEDDINV ALRQRTIAGE IQPMLCGTAF KNKGVQRMLD AVIDYLPSPA DIPPVDGQDD 310 320 330 340 350 360 DGNPIKRSAD DAEKFSALAF KLMSDPFVGQ LTFVRVYSGV LKSGDTVYNP IKGKKERIGR 370 380 390 400 410 420 LLQMHANNRE EIKEVLAGDI AAVVGLKDVT TGETLCDIDS HILLERMEFP EPVISQAVEP 430 440 450 460 470 480 KSKADQEKMG LALSRLAQED PSFRVRSDEE SGQTIISGMG ELHLEILVDR MRREFGVEAN 490 500 510 520 530 540 VGKPQVAYRE TIRKNCDEVE GKFVKQSGGR GQYGHVVLKL EPLPPGGGYE FVDAIKGGVV 550 560 570 580 590 600 PREYIPAVDK GIQETLPAGI LAGYPVVDVK ATLFFGSYHD VDSNENAFKM AASMAFKEGM 610 620 630 640 650 660 RRASPVLLEP MMAVEVETPE DYAGTVMGDL SSRRGMVQGM DDIVGGGKTI KAEVPLAEMF 670 680 690 700 GYATNLRSLT QGRATYTMEF KHYAEAPKNV ADEVIAARGK

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640437 Genomic DNA. Translation: CAE30528.1.
RefSeq	NP_886579.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q7WRC7.
SMR	Q7WRC7. Positions 1-695.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2662567.
GenomeReviews	Gene locus BB0026 in contig BX470250_GR.
KEGG	bbr:BB0026.
NMPDR	fig|257310.1.peg.26.
PATRIC	21133250. VBIBorBro124907_0027.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG737692.
OMA	CNEWREK.
PhylomeDB	Q7WRC7.
ProtClustDB	PRK00007.
Enzyme and pathway databases
BioCyc	BBRO257310:BB0026-MONOMER.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG1_BORBR

Accession

Primary (citable) accession number: Q7WRC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program