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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei62SubstrateUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Binding sitei231SubstrateUniRule annotation1
Binding sitei232NADUniRule annotation1
Binding sitei284NADUniRule annotation1
Binding sitei319NADUniRule annotation1
Binding sitei385NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 200NADUniRule annotation3
Nucleotide bindingi261 – 266NADUniRule annotation6
Nucleotide bindingi340 – 342NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Synonyms:acyH
Ordered Locus Names:BB0198
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

Q7WQX5:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169471 – 472AdenosylhomocysteinaseAdd BLAST472

Proteomic databases

PRIDEiQ7WQX5.

Interactioni

Protein-protein interaction databases

STRINGi257310.BB0198.

Structurei

3D structure databases

ProteinModelPortaliQ7WQX5.
SMRiQ7WQX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WQX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVTDKSVA DYIVADMALA GWGRRELAIA ETEMPGLMAI RDEYAASQPL
60 70 80 90 100
KGARIAGSLH MTIQTGVLIE TLVALGAEVR WASCNIFSTQ DHAAAAIAAT
110 120 130 140 150
GTPVFAIKGE TLEEYWQYTH KIFEWPEGRH ANMILDDGGD ATLLLHLGAR
160 170 180 190 200
AEQDISVLAK PGSEEERVLF AAIKETLARD PKWYSTRLAQ IKGVTEETTT
210 220 230 240 250
GVHRLYQMSQ KGELAFAAIN VNDSVTKSKF DNLYGCRESL VDGIKRATDV
260 270 280 290 300
MVAGKIAVVA GYGDVGKGCA QALAALRAQV WVTEIDPICA LQAAMEGFKV
310 320 330 340 350
VTMEEAAAHA DIFVTATGNY HVITRQHMEA MKDQAIVCNI GHFDNEIDVA
360 370 380 390 400
GLENCQWEEI KPQVDHVIFP DGKRIILLAK GRLVNLGCAT GHPSFVMSSS
410 420 430 440 450
FANQTIAQIE LFTRNEAYTT GQVYVLPKHL DEKVARLHLK KLGAKLSTLS
460 470
KQQADYIGVP VEGPFKPGHY RY
Length:472
Mass (Da):51,531
Last modified:October 1, 2003 - v1
Checksum:i7DA999B044D513E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640437 Genomic DNA. Translation: CAE30697.1.
RefSeqiWP_003807196.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE30697; CAE30697; BB0198.
KEGGibbr:BB0198.

Similar proteinsi

Entry informationi

Entry nameiSAHH_BORBR
AccessioniPrimary (citable) accession number: Q7WQX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families