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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciBBRO257310:G1GSX-250-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BB0248
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829241 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi257310.BB0248

Structurei

3D structure databases

ProteinModelPortaliQ7WQS8
SMRiQ7WQS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 120Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WQS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFAGTPE FARIALDALL AAGHDVPLVL TQPDRPAGRG LKLTPSPVKQ
60 70 80 90 100
AALAAGIEVA QPRSLRLDGR YPDEAAAARA QLERVAPDVM VVAAYGLILP
110 120 130 140 150
QWTLDLPRLG CLNIHASLLP RWRGAAPIQR AIEAGDAETG VTIMQMDAGL
160 170 180 190 200
DTGDMLLERA VPIGAQQTAA QLHDELALAG GQAIVDALAA LGQGGLAPRR
210 220 230 240 250
QPDAGVTYAA KLDKAEAALD CSLPAAVLAR RVRAFNPVPG ATIRLPGLDD
260 270 280 290 300
PVKVWRAQAL EQAAGGPPGA VLRADAQGID IATGQGVLRL LELQKAGGKR
310
QPVDVFVRGW QP
Length:312
Mass (Da):32,602
Last modified:October 1, 2003 - v1
Checksum:i1F70614C084D7B55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640437 Genomic DNA Translation: CAE30746.1
RefSeqiWP_003807302.1, NC_002927.3

Genome annotation databases

EnsemblBacteriaiCAE30746; CAE30746; BB0248
KEGGibbr:BB0248

Similar proteinsi

Entry informationi

Entry nameiFMT_BORBR
AccessioniPrimary (citable) accession number: Q7WQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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