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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BB0248
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829241 – 312Methionyl-tRNA formyltransferaseAdd BLAST312

Interactioni

Protein-protein interaction databases

STRINGi257310.BB0248.

Structurei

3D structure databases

ProteinModelPortaliQ7WQS8.
SMRiQ7WQS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni117 – 120Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiSCEIDSC.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiView protein in PROSITE
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WQS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFAGTPE FARIALDALL AAGHDVPLVL TQPDRPAGRG LKLTPSPVKQ
60 70 80 90 100
AALAAGIEVA QPRSLRLDGR YPDEAAAARA QLERVAPDVM VVAAYGLILP
110 120 130 140 150
QWTLDLPRLG CLNIHASLLP RWRGAAPIQR AIEAGDAETG VTIMQMDAGL
160 170 180 190 200
DTGDMLLERA VPIGAQQTAA QLHDELALAG GQAIVDALAA LGQGGLAPRR
210 220 230 240 250
QPDAGVTYAA KLDKAEAALD CSLPAAVLAR RVRAFNPVPG ATIRLPGLDD
260 270 280 290 300
PVKVWRAQAL EQAAGGPPGA VLRADAQGID IATGQGVLRL LELQKAGGKR
310
QPVDVFVRGW QP
Length:312
Mass (Da):32,602
Last modified:October 1, 2003 - v1
Checksum:i1F70614C084D7B55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640437 Genomic DNA. Translation: CAE30746.1.
RefSeqiWP_003807302.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE30746; CAE30746; BB0248.
KEGGibbr:BB0248.
PATRICi21133698. VBIBorBro124907_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640437 Genomic DNA. Translation: CAE30746.1.
RefSeqiWP_003807302.1. NC_002927.3.

3D structure databases

ProteinModelPortaliQ7WQS8.
SMRiQ7WQS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB0248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE30746; CAE30746; BB0248.
KEGGibbr:BB0248.
PATRICi21133698. VBIBorBro124907_0251.

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiSCEIDSC.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiView protein in PROSITE
PS00373. GART. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFMT_BORBR
AccessioniPrimary (citable) accession number: Q7WQS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: March 15, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.