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Q7WPH6 (GLYA1_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 1
Short name=SHMT 1
Short name=Serine methylase 1
EC=2.1.2.1
Gene names
Name:glyA1
Ordered Locus Names:BB0708
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier By similarity.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Pyridoxal-phosphate-dependent serine hydroxymethyltransferase 1
PRO_0000113537

Regions

Region136 – 1383Substrate binding By similarity

Sites

Binding site461Pyridoxal phosphate By similarity
Binding site661Pyridoxal phosphate By similarity
Binding site681Substrate By similarity
Binding site751Substrate binding By similarity
Binding site761Pyridoxal phosphate By similarity
Binding site1101Pyridoxal phosphate By similarity
Binding site1321Substrate By similarity
Binding site1871Pyridoxal phosphate By similarity
Binding site2151Pyridoxal phosphate By similarity
Binding site2401Pyridoxal phosphate By similarity
Binding site2471Pyridoxal phosphate By similarity
Binding site2731Pyridoxal phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site3731Pyridoxal phosphate By similarity

Amino acid modifications

Modified residue2411N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WPH6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5C0C3140224A0911

FASTA43045,219
        10         20         30         40         50         60 
MNDLLPAAAA PAGARALPLR HADPEIWRAV DAERQRQMHS IELIASENFV SQAVLDAQGS 

        70         80         90        100        110        120 
VMTNKYAEGY PGRRYYGGCR HVDVAERAAI ERARRLFGCE YANVQPHSGS QANQAVYLAL 

       130        140        150        160        170        180 
LAPGDRILGL DLKAGGHLTH GAHVNLSGKW FEALSYGVDP VSHRIDMDEV ERTARRERPR 

       190        200        210        220        230        240 
LIIAGGSAYA RVPDFARFRA IADATGALFV ADMAHYAGLV AGGAFPSPVP FAHVTTTTTH 

       250        260        270        280        290        300 
KTLRGPRGGM ILTDDADIAR RIDAAVFPGL QGGPLMHVIA AKAVALGEAL QPGFRAYARA 

       310        320        330        340        350        360 
VIDNARALCA RLAEGGLSIV SGGTDCHLGV VDLRPWGLAG NAAERALEEA GITVNKNAVP 

       370        380        390        400        410        420 
GDAASPAVTS GIRVGSAACT SRGMGPAEFR QIGDLVLAVL GGLRDGGQAG GRDAVPARAA 

       430 
ELSRRFPLPY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640439 Genomic DNA. Translation: CAE31208.1.
RefSeqNP_887258.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WPH6.
SMRQ7WPH6. Positions 19-400.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2663126.
GenomeReviewsGene locus BB0708 in contig BX470250_GR.
KEGGbbr:BB0708.
NMPDRfig|257310.1.peg.705.
PATRIC21134633. VBIBorBro124907_0714.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG301263.
OMASHRIDMD.
PhylomeDBQ7WPH6.
ProtClustDBPRK13034.

Enzyme and pathway databases

BioCycBBRO257310:BB0708-MONOMER.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYA1_BORBR
AccessionPrimary (citable) accession number: Q7WPH6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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