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Protein

Arginase

Gene

BB0835

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 2 manganese ions per subunit.
  • Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

GO - Molecular functioni

  1. arginase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Biological processi

Arginine metabolismUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBBRO257310:BB0835-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ArginaseUniRule annotation (EC:3.5.3.1UniRule annotation)
Gene namesi
Ordered Locus Names:BB0835Imported
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)Imported
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi257310.BB0835.

Structurei

3D structure databases

ProteinModelPortaliQ7WP50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000268676.
KOiK01476.
OMAiITVHDMR.
OrthoDBiEOG6BKJ5H.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WP50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAASFPHGV SLIGAPTDIG AGQRGASMGP EALRVAGLVR LLERRGLQVT
60 70 80 90 100
DRGNLQGAPN PWRPPANGYR HLNEVIGWNQ LVHDAVSAEL RQERLPILLG
110 120 130 140 150
GDHSLAIGSI SAVARHCRAS GRKLRVLWLD AHADFNTNRL TPTGNVHGMP
160 170 180 190 200
VACLCGNGPA ALTGMAGRTP AIEPGWVRQI GIRSVDEGER NLVYDAGLEV
210 220 230 240 250
YDMRYLDEVG MRAVMEAALA GLDPQTHLHV SFDVDFLDPE LAPGVGTTVP
260 270 280 290 300
GGPTYREAQL CMEMIADTGL MRSLDIVELN PALDVRNKTA QVAVDLVESL
310
FGKSTLMRRR PGSA
Length:314
Mass (Da):33,666
Last modified:October 1, 2003 - v1
Checksum:i9D95D6F24C0FA190
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640439 Genomic DNA. Translation: CAE31334.1.
RefSeqiNP_887384.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE31334; CAE31334; BB0835.
KEGGibbr:BB0835.
PATRICi21134887. VBIBorBro124907_0841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640439 Genomic DNA. Translation: CAE31334.1.
RefSeqiNP_887384.1. NC_002927.3.

3D structure databases

ProteinModelPortaliQ7WP50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB0835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE31334; CAE31334; BB0835.
KEGGibbr:BB0835.
PATRICi21134887. VBIBorBro124907_0841.

Phylogenomic databases

HOGENOMiHOG000268676.
KOiK01476.
OMAiITVHDMR.
OrthoDBiEOG6BKJ5H.

Enzyme and pathway databases

BioCyciBBRO257310:BB0835-MONOMER.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50Imported.

Entry informationi

Entry nameiQ7WP50_BORBR
AccessioniPrimary (citable) accession number: Q7WP50
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.