Q7WP31 (GCST_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BB0854

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_0000122546

Sequences

	Sequence		Length	Mass (Da)
	Q7WP31 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 5155BCD472434C97	FASTA	366	39,342
	10 20 30 40 50 60 MSAPLKRTPL AEEHLAAGAR MVDFGGWDMP LAYGSQLEEH HAVRQDAGMF DVSHMLNVDV 70 80 90 100 110 120 GGADATAFLR RLVANDVARL ATPGKALYSC MLNPQGGIID DLIIYYFAPD QWRVVVNAGT 130 140 150 160 170 180 ADKDIAWMQR VAAADGFDVA IAPRRDLAMV AVQGPNARAK VWAARPAWQA ASEPLAPFSA 190 200 210 220 230 240 AAVEAGTLVA RTGYTGEDGF EIVLPADAVV QLWRDLLAQG VRPCGLGARD TLRLEAGMNL 250 260 270 280 290 300 YGQDMDELVH PDQAGLSWTV ALKDEARRFV GRDAIEQFAV PRAFVGLKLQ ERGVMRAHMP 310 320 330 340 350 360 VRCAQGMGEL TSGTMSPTLG VSVGFARVPV GVQPGDAVEV EIRGKWVPAL VCKLPFVRHG KAVEHS

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640439 Genomic DNA. Translation: CAE31353.1.
RefSeq	NP_887403.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q7WP31.
SMR	Q7WP31. Positions 7-364.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2660134.
GenomeReviews	Gene locus BB0854 in contig BX470250_GR.
KEGG	bbr:BB0854.
NMPDR	fig|257310.1.peg.850.
PATRIC	21134925. VBIBorBro124907_0860.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q7WP31.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	BBRO257310:BB0854-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BORBR

Accession

Primary (citable) accession number: Q7WP31

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program