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Q7WP29 (GCSP_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BB0856
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166904

Amino acid modifications

Modified residue7011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WP29 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 2F08D4F14716B0D6

FASTA954102,137
        10         20         30         40         50         60 
MSRAPDTHSD FIPRHIGPSD EDQATMLAAI GAASLDALID EVVPPRIRSR APLALPAARS 

        70         80         90        100        110        120 
ETDVLQDLKR MAARNQIYRN YIGQGYYGTH TPNVVLRNVL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNYQTM VADLTGLDIS NASLLDEGTA AAEAMTLARR GSRSSSPVFF VSQHCHPQTL 

       190        200        210        220        230        240 
EVVRTRAEGL GIELVIGDES RGLPECFGVL LQYPHSLGGV ADYRELAQAA HAQGAVVACV 

       250        260        270        280        290        300 
TDLLALALIE PPGQWGADIA VGSAQRFGVP FGFGGPHAGF MSCRDAYKRN MPGRLVGVSK 

       310        320        330        340        350        360 
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPRG VRRIAERVQS 

       370        380        390        400        410        420 
LTGALRAALA GLGVKVANDT WFDTLLLETG VATPAILAAA DCARINLRQV DGARLAVSLD 

       430        440        450        460        470        480 
ETVTLADLQA LVNVFAAGLG KDEVALPAPQ ASLDGIPAAV RRQGPILSHP VFSSVQSETD 

       490        500        510        520        530        540 
MLRYLRKLAD KDLALDRTMI PLGSCTMKLN ATAEMIPITW PEFALIHPFA PASQTPGYRE 

       550        560        570        580        590        600 
LIDGLSAQLC EITGYDGISL QPNSGAQGEY AGLLAIRAYH QANGQPQRNV CLIPASAHGT 

       610        620        630        640        650        660 
NPASAQLAGM DVVVVASDAN GNVDLADLRA RIAQVGERLA ALMITYPSTH GVFEEAVTEI 

       670        680        690        700        710        720 
CDAVHEAGGQ VYLDGANMNA MVGVAQPGKF GSDVSHLNLH KTFCIPHGGG GPGVGPVAVR 

       730        740        750        760        770        780 
AHLAPYLPGV LDAQGRLDPE AKVGPVSAAP YGSAGILPIP YVYIALMGAE GLRRATEVAI 

       790        800        810        820        830        840 
LNANYIAARL RDHYPVLYAG RNGRVAHECI LDVRPLKETS GISAEDIAKR LMDYGFHAPT 

       850        860        870        880        890        900 
MSFPVAGTLM VEPTESEGLA ELERFIEAMI AIRAEIAQIE SGERDRDDNV LRNAPHTAQM 

       910        920        930        940        950 
LLAEEWHHDY PRQQAAYPVA SLRENKYWPP VARVDNAYGD RNLVCACLPV EAYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640439 Genomic DNA. Translation: CAE31355.1.
RefSeqNP_887405.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WP29.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257310.BB0856.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE31355; CAE31355; BB0856.
GeneID2661761.
KEGGbbr:BB0856.
PATRIC21134931. VBIBorBro124907_0863.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycBBRO257310:BB0856-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BORBR
AccessionPrimary (citable) accession number: Q7WP29
Entry history
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families