Reviewed,
UniProtKB/Swiss-Prot Q7WNZ3 (HGD_BORBR)
Last modified
November 3, 2009.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisicase Homogentisate oxygenase Homogentisic acid oxidase | ||||
| Gene names |
| ||||
| Organism | Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 518 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella |
Protein attributes
| Sequence length | 432 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334 |
| Cofactor | Iron By similarity. |
| Pathway | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334 |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 432 | 432 | Homogentisate 1,2-dioxygenase HAMAP MF_00334 | PRO_0000225782 | |||||
Sites | |||||||||
| Metal binding | 329 | 1 | Iron By similarity | ||||||
| Metal binding | 335 | 1 | Iron By similarity | ||||||
| Metal binding | 365 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J.Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252. |
Cross-references
Sequence databases | |
|---|---|
| BX640439 Genomic DNA. Translation: CAE31391.1. | |
| RefSeq | NP_887441.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1EYB based on UniProtKB Q93099. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 2663339. |
| GenomeReviews | Gene locus BB0892 in contig BX470250_GR. |
| KEGG | bbr:BB0892. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q7WNZ3. |
| OMA | HRNCMSE. |
Enzyme and pathway databases | |
| BioCyc | BBRO257310:BB0892-MON. |
| BRENDA | 1.13.11.5. 413. |
Family and domain databases | |
| HAMAP | MF_00334. [Tree] |
| InterPro | IPR005708. Homogentis_dOase. [Graphical view] |
| PANTHER | PTHR11056. Homogentis_dOase. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_BORBR | ||||||||
| Accession | Primary (citable) accession number: Q7WNZ3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


