Q7WNZ3 (HGD_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homogentisate 1,2-dioxygenase
EC=1.13.11.5

Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase

Gene names

Name:	hmgA
Ordered Locus Names:	BB0892

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › Bordetella bronchiseptica

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334		PRO_0000225782
Sites
	Metal binding	329	1	Iron By similarity
	Metal binding	335	1	Iron By similarity
	Metal binding	365	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7WNZ3 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 61EC71A083C2CE66	FASTA	432	48,039
	10 20 30 40 50 60 MSLQYQTGFG NACATEALPG ALPAGRNSPQ ICPYGLYAEQ LSGTAFTAPR AENRRSWLYR 70 80 90 100 110 120 IRPGVQHLPF APFAGAQRWL SDFGRQPVTP NQLRWSPLPM PDAPTDFIDG MHTWGGNGGP 130 140 150 160 170 180 EEQSGVGIHL YAANRSMQGR FFYNADGEML IVPQQGRLRL ATELGLIDIE PYEIAVVPRG 190 200 210 220 230 240 VRLRVELLDD VARGYMLENF GTAMRLPELG PIGSNCLANA RDFQIPVAWY EDVEGDFELI 250 260 270 280 290 300 AKFTGGFWRA PIAHSPLNVV AWHGTHAPYK YDLRNFNTVG SISYDHPDPS IFTVLTSPSD 310 320 330 340 350 360 TPGTANMDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI HGVYDAKAEG FAPGGASLHN 370 380 390 400 410 420 CMSGHGPDAD TFEKASHADT SQAHYIRDTM AFMFETRRVI RPTAQALASP QRQDDYYQCW 430 QGLQKHFDPE QA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640439 Genomic DNA. Translation: CAE31391.1.
RefSeq	NP_887441.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q7WNZ3.
ModBase	Search...
Protein-protein interaction databases
STRING	257310.BB0892.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE31391; CAE31391; BB0892.
GeneID	2663339.
KEGG	bbr:BB0892.
PATRIC	21135007. VBIBorBro124907_0901.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3508.
HOGENOM	HOG000139824.
KO	K00451.
OMA	AVTKWGL.
ProtClustDB	PRK05341.
Enzyme and pathway databases
BioCyc	BBRO257310:BB0892-MONOMER.
UniPathway	UPA00139; UER00339.
Family and domain databases
Gene3D	2.60.120.10. 2 hits.
HAMAP	MF_00334. Homogentis_dioxygen.
InterPro	IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view]
PANTHER	PTHR11056. PTHR11056. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_BORBR

Accession

Primary (citable) accession number: Q7WNZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program