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Q7WLL4

- UPPP_BORBR

UniProt

Q7WLL4 - UPPP_BORBR

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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. dephosphorylation Source: InterPro
  3. peptidoglycan biosynthetic process Source: UniProtKB-KW
  4. regulation of cell shape Source: UniProtKB-KW
  5. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBBRO257310:BB1731-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:BB1731
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Undecaprenyl-diphosphatasePRO_0000151113Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257310.BB1731.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6521HelicalUniRule annotationAdd
BLAST
Transmembranei89 – 10921HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei204 – 22421HelicalUniRule annotationAdd
BLAST
Transmembranei238 – 25821HelicalUniRule annotationAdd
BLAST
Transmembranei266 – 28621HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFAWWRIV.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WLL4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSTLHLLK AFFLGIVEGL TEFIPVSSTG HLIVIGDWIN FASSSGKVFE
60 70 80 90 100
VVIQFGSILA VMWIFRARLW QLIRGTLTGV RQEVNFTRNL LLAFLPAAVI
110 120 130 140 150
GAIFIKSIKQ VFYHPGVVAV TLVVGGFIML WVERRAPHTP GDAPGAADDT
160 170 180 190 200
ASDERATAHT LEQISAKQAL GVGVAQCVAM IPGVSRSGAT IIGGMIAGIQ
210 220 230 240 250
RKTATEFSFF LAMPTMLGAA VYDLYRNIGL LSQHDMSAIA VGFVAAFLSA
260 270 280
LVVVRAVLRF VANHTYRVFA WYRIALGLVV AAWIYAK
Length:287
Mass (Da):31,014
Last modified:October 1, 2003 - v1
Checksum:i233AEE2164F16A13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640442 Genomic DNA. Translation: CAE32228.1.
RefSeqiNP_888276.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE32228; CAE32228; BB1731.
GeneIDi2661924.
KEGGibbr:BB1731.
PATRICi21136732. VBIBorBro124907_1751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640442 Genomic DNA. Translation: CAE32228.1 .
RefSeqi NP_888276.1. NC_002927.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257310.BB1731.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE32228 ; CAE32228 ; BB1731 .
GeneIDi 2661924.
KEGGi bbr:BB1731.
PATRICi 21136732. VBIBorBro124907_1751.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FAWWRIV.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BBRO257310:BB1731-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiUPPP_BORBR
AccessioniPrimary (citable) accession number: Q7WLL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3