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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BB1913
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477031 – 265GTP cyclohydrolase FolE2Add BLAST265

Proteomic databases

PRIDEiQ7WL36

Interactioni

Protein-protein interaction databases

STRINGi257310.BB1913

Structurei

3D structure databases

ProteinModelPortaliQ7WL36
SMRiQ7WL36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiPYSSTCP
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WL36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPIDPAIV MPDVQSSTDT RHIPIQRVGI RGVRHPMLVL AGDGAAQPTV
60 70 80 90 100
ANWTLTVALP AEEKGTHMSR FVALLEKYRA TPMTPALFAA MAREMLPLLH
110 120 130 140 150
AERGDITASF PYFINKSAPV SGVQSLLDYE MQWIARAVGE QVEFELVAQV
160 170 180 190 200
PVTSLCPCSK AISEYGAHNQ RSHVTVSAIV DGDFRMDELI RLVEDEASCE
210 220 230 240 250
LWGLLKRPDE KYVTERAYDN PKFVEDLVRD VAARLKAHPG IGRFRVEAEN
260
FESIHNHSAY AVVEG
Length:265
Mass (Da):29,365
Last modified:October 1, 2003 - v1
Checksum:i4B4F4387ED84A0B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640442 Genomic DNA Translation: CAE32410.1
RefSeqiWP_003813103.1, NC_002927.3

Genome annotation databases

EnsemblBacteriaiCAE32410; CAE32410; BB1913
KEGGibbr:BB1913

Similar proteinsi

Entry informationi

Entry nameiGCH4_BORBR
AccessioniPrimary (citable) accession number: Q7WL36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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