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Q7WL36 (GCH4_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BB1913
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000147703

Sites

Site1561May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WL36 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 4B4F4387ED84A0B6

FASTA26529,365
        10         20         30         40         50         60 
MNSPIDPAIV MPDVQSSTDT RHIPIQRVGI RGVRHPMLVL AGDGAAQPTV ANWTLTVALP 

        70         80         90        100        110        120 
AEEKGTHMSR FVALLEKYRA TPMTPALFAA MAREMLPLLH AERGDITASF PYFINKSAPV 

       130        140        150        160        170        180 
SGVQSLLDYE MQWIARAVGE QVEFELVAQV PVTSLCPCSK AISEYGAHNQ RSHVTVSAIV 

       190        200        210        220        230        240 
DGDFRMDELI RLVEDEASCE LWGLLKRPDE KYVTERAYDN PKFVEDLVRD VAARLKAHPG 

       250        260 
IGRFRVEAEN FESIHNHSAY AVVEG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640442 Genomic DNA. Translation: CAE32410.1.
RefSeqNP_888458.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WL36.
SMRQ7WL36. Positions 22-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257310.BB1913.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE32410; CAE32410; BB1913.
GeneID2661835.
KEGGbbr:BB1913.
PATRIC21137122. VBIBorBro124907_1938.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAIAMTACP.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycBBRO257310:BB1913-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BORBR
AccessionPrimary (citable) accession number: Q7WL36
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways