Reviewed, UniProtKB/Swiss-Prot Q7WKJ5 (AROC_BORBR)

Names and origin

Protein names

Recommended name:
    Chorismate synthase
    EC=4.2.3.5
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BB2111

Organism

Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

518 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Chorismate synthase HAMAP MF_00300		PRO_0000140557

Sequences

	Sequence		Length	Mass (Da)
	Q7WKJ5-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: B5B55ED965F6A970	FASTA	353	37,274
	10 20 30 40 50 60 MSGNTLGTLF CVTNFGESHG PAIGCVVDGC PPGLPLEAAD IQAELDRRRP GTSRHVTQRQ 70 80 90 100 110 120 EADQVEILSG VYEGVTTGTP IGLLIRNTDA RSKDYSNIAD TFRPGHADFA YWRKYGVRDP 130 140 150 160 170 180 RGGGRSSARL TAPTVAAGAI AKKWLAGQFG VRVRGYMSQL GPIAIPFSSW DDVPGNAFYA 190 200 210 220 230 240 PNAAVVPELE AYMDQLRRDG DSVGARIEVV AEGLPAGWGE PIYDRLDADI AHAMMGLNAV 250 260 270 280 290 300 KGVSLGAGFE SIAQRGSEHG DEITPEGFAS NHAGGVLGGI STGQPITVSL AIKPTSSIRV 310 320 330 340 350 ERRSVNRAGE PVMVQTLGRH DPCVGIRATP IAEALLALVL IDHALRQRAQ CGG

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640443 Genomic DNA. Translation: CAE32607.1.
RefSeq	NP_888654.1.
3D structure databases
HSSP	HSSP built from PDB template 1Q1L based on UniProtKB O66493.
ModBase	Search...
Genome annotation databases
GeneID	2661324.
GenomeReviews	Gene locus BB2111 in contig BX470250_GR.
KEGG	bbr:BB2111.
NMPDR	fig|257310.1.peg.2101.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7WKJ5.
OMA	SRFTTQR.
Enzyme and pathway databases
BioCyc	BBRO257310:BB2111-MON.
BRENDA	4.2.3.5. 413.
Family and domain databases
HAMAP	MF_00300. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
ProDom	PD002941. Chorismate_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00033. aroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BORBR

Accession

Primary (citable) accession number: Q7WKJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)