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Q7WJ88 (DXR_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Short name=DXP reductoisomerase
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name:dxr
Ordered Locus Names:BB2611
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183

Cofactor

Divalent cation By similarity. HAMAP MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183

Sequence similarities

Belongs to the DXR family.

Ontologies

Keywords
   Biological processIsoprene biosynthesis
   LigandMetal-binding
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function1-deoxy-D-xylulose-5-phosphate reductoisomerase activity

Inferred from electronic annotation. Source: EC

NADPH binding

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3993991-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
PRO_0000163618

Regions

Nucleotide binding10 – 3930NADP By similarity

Sites

Metal binding1531Divalent metal cation By similarity
Metal binding1551Divalent metal cation By similarity
Metal binding2321Divalent metal cation By similarity
Binding site1281Substrate By similarity
Binding site1551Substrate By similarity
Binding site1871Substrate By similarity
Binding site2101Substrate By similarity
Binding site2321Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WJ88 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8319C8E5B9748768

FASTA39942,097
        10         20         30         40         50         60 
MTRFQRVAVL GSTGSIGDST LDVIARHPDR LGVYALSAYS RMDKLAAQAA ACGAAVVVVP 

        70         80         90        100        110        120 
DDAAAARFRA AWRGKAAMPE VRVGPRALAE TAAAPECTTV MAAIVGAAGL PAALAAAQAG 

       130        140        150        160        170        180 
KRVLLANKEA LVAAGSLFMA AVRENGAELL PIDSEHNAIF QCMPQGARAA APTAPAPGVR 

       190        200        210        220        230        240 
RLLLTASGGP FRRQDPADLH EVTPAQACAH PNWSMGRKIS VDSATMLNKG LEVIEAHWLF 

       250        260        270        280        290        300 
AMPSERIDVL IHPQSVVHSM VEYDDGSVLA QLGQPDMRTP IAYGLGFPER LASGVGLLDL 

       310        320        330        340        350        360 
TRWGRLDFEQ PDLQRFPCLA LSFAALRAGQ PACVALNAAN EVAVAAFLEG RLRYTWIARV 

       370        380        390 
IEAVLEWQAK QASVTLTSLD DVLDLDARAR SFAGNLGLA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640444 Genomic DNA. Translation: CAE33104.1.
RefSeqNP_889148.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WJ88.
SMRQ7WJ88. Positions 5-396.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2659809.
GenomeReviewsGene locus BB2611 in contig BX470250_GR.
KEGGbbr:BB2611.
PATRIC21138557. VBIBorBro124907_2647.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG430762.
OMAIHSMVEY.
PhylomeDBQ7WJ88.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycBBRO257310:BB2611-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR_BORBR
AccessionPrimary (citable) accession number: Q7WJ88
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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