Q7WJ81 (LPXB_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid-A-disaccharide synthase
EC=2.4.1.182

Gene names

Name:	lpxB
Synonyms:	pgsB
Ordered Locus Names:	BB2618

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00392
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP MF_00392
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP MF_00392
Sequence similarities	Belongs to the LpxB family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Lipid-A-disaccharide synthase HAMAP MF_00392		PRO_0000190152

Sequences

	Sequence		Length	Mass (Da)
	Q7WJ81 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C1482799F9CBC38C	FASTA	393	42,748
	10 20 30 40 50 60 MSLRIGMVAG EPSGDLLAGR IIAGLQARAP GVHCAGIGGP QMAARGFEAW HPMHALTVFG 70 80 90 100 110 120 YIDAFKRIPS LLSTYGDVKR RLLAEPPSVF VGIDAPDFNL RLEHQLRQAG TPTVHFVGPS 130 140 150 160 170 180 IWAWRYERIN KIRAAVSHML VLFPFEEALY RKEGIPVTYV GHPLAGVIPM QPDRAAARAR 190 200 210 220 230 240 LGIDADARVL AILPGSRSSE IRLLAPRFLQ AAAELVRRDP RLQCVVPMVN PQRRAEFEAI 250 260 270 280 290 300 AAQHPVPGLR CVTAAEGQGE TPVAWSVMEA SNAVLVASGT ATLETALYKR PMVISYVLSP 310 320 330 340 350 360 WMRRIMAWKS GQQRPYLPWV GLPNVLLRDF AVPELLQDEA TPAALAEATW QALTDEAGAA 370 380 390 RIEARFTALH QDLLRDTPAL AAQAILEVAD GAA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640444 Genomic DNA. Translation: CAE33111.1.
RefSeq	NP_889155.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q7WJ81.
ModBase	Search...
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2661937.
GenomeReviews	Gene locus BB2618 in contig BX470250_GR.
KEGG	bbr:BB2618.
PATRIC	21138571. VBIBorBro124907_2654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
PhylomeDB	Q7WJ81.
ProtClustDB	PRK00025.
Enzyme and pathway databases
BioCyc	BBRO257310:BB2618-MONOMER.
Family and domain databases
HAMAP	MF_00392. LpxB. [Tree]
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXB_BORBR

Accession

Primary (citable) accession number: Q7WJ81

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program