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Protein

Formimidoylglutamase

Gene

hutG

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.UniRule annotation

Catalytic activityi

N-formimidoyl-L-glutamate + H2O = L-glutamate + formamide.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formimidoylglutamase (hutG)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from N-formimidoyl-L-glutamate (hydrolase route), the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124Manganese 1UniRule annotation1
Metal bindingi153Manganese 1UniRule annotation1
Metal bindingi153Manganese 2UniRule annotation1
Metal bindingi155Manganese 2UniRule annotation1
Metal bindingi157Manganese 1UniRule annotation1
Metal bindingi244Manganese 1UniRule annotation1
Metal bindingi244Manganese 2UniRule annotation1
Metal bindingi246Manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processHistidine metabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00379; UER00552

Names & Taxonomyi

Protein namesi
Recommended name:
FormimidoylglutamaseUniRule annotation (EC:3.5.3.8UniRule annotation)
Alternative name(s):
FormiminoglutamaseUniRule annotation
Formiminoglutamate hydrolaseUniRule annotation
Gene namesi
Name:hutGUniRule annotation
Ordered Locus Names:BB2645
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737501 – 317FormimidoylglutamaseAdd BLAST317

Interactioni

Protein-protein interaction databases

STRINGi257310.BB2645

Structurei

3D structure databases

ProteinModelPortaliQ7WJ55
SMRiQ7WJ55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41088SP Bacteria
COG0010 LUCA
HOGENOMiHOG000237658
KOiK01479
OMAiNFDAHLD
OrthoDBiPOG091H04CY

Family and domain databases

HAMAPiMF_00737 Formimidoylglutam, 1 hit
InterProiView protein in InterPro
IPR005923 HutG
IPR006035 Ureohydrolase
IPR023696 Ureohydrolase_dom_sf
IPR020855 Ureohydrolase_Mn_BS
PfamiView protein in Pfam
PF00491 Arginase, 1 hit
PIRSFiPIRSF036979 Arginase, 1 hit
PRINTSiPR00116 ARGINASE
SUPFAMiSSF52768 SSF52768, 1 hit
TIGRFAMsiTIGR01227 hutG, 1 hit
PROSITEiView protein in PROSITE
PS01053 ARGINASE_1, 1 hit
PS51409 ARGINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WJ55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVANDSASI WTARDDSGER GDTRRLAHIV ALGQDAGAGD AAVLGFACDA
60 70 80 90 100
GVARNQGRRG AALAPRAIRR MMAGLPAHNL RRLVDAGDVV CEDDQLEAAQ
110 120 130 140 150
DALAGRVAAL LQAGAHPVVL GGGHEIAWGS FQGLRRWLDA RGDREPVLVL
160 170 180 190 200
NLDAHFDLRT GRPGSSGTPF DQIAEYCAAR GHALQYACLG VSPLGNTPAL
210 220 230 240 250
YARAAEVGAV WVEDRHMQEA HLGERLAQLD ALLAAAGHVY LTIDLDVLPA
260 270 280 290 300
ATAPGVSAPA PYGVPLAVVE EVAMHVRASG KLRLADLAEC NPAYDIDHRT
310
ARVAARLAWR LLGGAAR
Length:317
Mass (Da):33,275
Last modified:October 1, 2003 - v1
Checksum:iBE1410B8EC1D3C6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640445 Genomic DNA Translation: CAE33138.1
RefSeqiWP_010926579.1, NC_002927.3

Genome annotation databases

EnsemblBacteriaiCAE33138; CAE33138; BB2645
KEGGibbr:BB2645

Similar proteinsi

Entry informationi

Entry nameiHUTG_BORBR
AccessioniPrimary (citable) accession number: Q7WJ55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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