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Protein

Glutamate decarboxylase

Gene

BB2658

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBBRO257310:BB2658-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:BB2658Imported
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)Imported
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi257310.BB2658.

Structurei

3D structure databases

ProteinModelPortaliQ7WJ42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WJ42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSPEQMTP YDQFNIEVPE DHFPVEGMSA RAAQALVLSD EWTDTNPMLN
60 70 80 90 100
MSSFVTTFAE PEAVRIAEKN MYKNYIDHDM YPQLFAMEQR MVRWLHQLWN
110 120 130 140 150
GPKDAEPYGT ATVGSSEACM LAGLAHKWNW RQRREREGKD ATRPNMVTGG
160 170 180 190 200
NVQIVWKKFL RYFDVEPRIV PLKPGQYCLT AEDLDKYVDE NTIAVVAIAG
210 220 230 240 250
QTFTGEDDDI QGIHDWLDAY EKKTGVSVPM HIDGASGGFV NPFLYPDYKW
260 270 280 290 300
DFRLPRVQSI NASGHKYGLT PPGLGWVIFR ERKVFNEDLV FYVNYLGGEM
310 320 330 340 350
PTATLNFSRN SFQVAVQYYQ FLRLGFDGFK RVMQRTLDNA IALRQHLVDS
360 370 380 390 400
GYFTIMNDTQ RIPVVAVTLD PKVKKFNEFD VSNKVRERGW VISAYTMPPD
410 420 430 440 450
AESVRSLRVV VRPHINRNVA LLLAEDIVKA CKYLEQHGGT ATPPALHDTH

KSSPAKC
Length:457
Mass (Da):52,136
Last modified:October 1, 2003 - v1
Checksum:iDC29E2FFF68156B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640445 Genomic DNA. Translation: CAE33151.1.
RefSeqiNP_889195.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33151; CAE33151; BB2658.
GeneIDi2660173.
KEGGibbr:BB2658.
PATRICi21138651. VBIBorBro124907_2694.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640445 Genomic DNA. Translation: CAE33151.1.
RefSeqiNP_889195.1. NC_002927.3.

3D structure databases

ProteinModelPortaliQ7WJ42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB2658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE33151; CAE33151; BB2658.
GeneIDi2660173.
KEGGibbr:BB2658.
PATRICi21138651. VBIBorBro124907_2694.

Phylogenomic databases

HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciBBRO257310:BB2658-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50Imported.

Entry informationi

Entry nameiQ7WJ42_BORBR
AccessioniPrimary (citable) accession number: Q7WJ42
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.