Reviewed, UniProtKB/Swiss-Prot Q7WIF7 (PSD_BORBR)

Names and origin

Protein names

Recommended name:
    Phosphatidylserine decarboxylase proenzyme
    EC=4.1.1.65
Cleaved into the following 2 chains:
    1- Recommended name:
            Phosphatidylserine decarboxylase alpha chain
    2- Recommended name:
            Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BB2894

Organism

Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

518 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00662
Cofactor	Pyruvoyl group By similarity.
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00662
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029633
	Chain	254 – 297	44	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029634
Sites
	Site	253 – 254	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	254	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7WIF7-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 02861DB2565FAF43	FASTA	297	32,586
	10 20 30 40 50 60 MPFKDQLFLA SQYLAPHHLV SRLMGRAADC RAPEIKNRMI ARFVRRYNVD MSEALVEDPL 70 80 90 100 110 120 AYASFNDFFT RALKPDARPL DDEPGAALCP ADGAISQIGA IDNGRIFQAK GHSFGLTDLL 130 140 150 160 170 180 GGDAERAAPF AGGQFATIYL SPRDYHRVHM PLAGTLREMV HVPGRLFSVN PLTARSVPEL 190 200 210 220 230 240 FARNERVACL FDTEHGPMAL VLVGAMIVAS IETVWAGLVT PHKRQVRSVR YDAAARAPIH 250 260 270 280 290 LDKGAEMGRF KLGSTVIVLF GPKRLRWLDL PSVRGPVRMG ETLALPASTA ISFPESE

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640445 Genomic DNA. Translation: CAE33386.1.
RefSeq	NP_889430.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2660848.
GenomeReviews	Gene locus BB2894 in contig BX470250_GR.
KEGG	bbr:BB2894.
NMPDR	fig|257310.1.peg.2877.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7WIF7.
OMA	ALFSVNP.
Enzyme and pathway databases
BioCyc	BBRO257310:BB2894-MON.
BRENDA	4.1.1.65. 413.
Family and domain databases
HAMAP	MF_00662. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR005221. PS_decarb. [Graphical view]
PANTHER	PTHR10067. PS_decarb. 1 hit.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00163. PS_decarb. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BORBR

Accession

Primary (citable) accession number: Q7WIF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)