Reviewed, UniProtKB/Swiss-Prot Q7WI95 (NTPA_BORBR)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BB2956

Organism

Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

518 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H(2)O = NDP + phosphate.
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Nucleoside-triphosphatase		PRO_0000178135

Sequences

	Sequence		Length	Mass (Da)
	Q7WI95-1 [UniParc]. Last modified April 26, 2005. Version 2. Checksum: E28CCDC43979B94C	FASTA	213	22,591
	10 20 30 40 50 60 MSAEILNPNL RRVVLASNNA GKLREFSALF APLGIELVPQ SELGVSEAEE PHATFVENAL 70 80 90 100 110 120 AKARHASRHT GLPALADDSG LCVVALGGAP GVHSARYAQQ PGGARSDAAN NALLVRELAA 130 140 150 160 170 180 AGDRRAWYVA LLALVRTEND PCPLIGEGLW HGEIVDAPAG EHGFGYDPHF YLPQQGCTAA 190 200 210 QLAPEHKNRI SHRAQALAQL LDKLRATGPV DRP

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640446 Genomic DNA. Translation: CAE33448.1. Different initiation.
3D structure databases
HSSP	HSSP built from PDB template 1K7K based on UniProtKB P52061.
ModBase	Search...
Genome annotation databases
GenomeReviews	Gene locus BB2956 in contig BX470250_GR.
KEGG	bbr:BB2956.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7WI95.
Enzyme and pathway databases
BioCyc	BBRO257310:BB2956-MON.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p_like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BORBR

Accession

Primary (citable) accession number: Q7WI95

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	July 22, 2008
This is version 27 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)