SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7WH33

- SYL_BORBR

UniProt

Q7WH33 - SYL_BORBR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Leucine--tRNA ligase
Gene
leuS, BB3377
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei642 – 6421ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRO257310:BB3377-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BB3377
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligaseUniRule annotation
PRO_0000151979Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257310.BB3377.

Structurei

3D structure databases

ProteinModelPortaliQ7WH33.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi639 – 6435"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WH33-1 [UniParc]FASTAAdd to Basket

« Hide

MQERYQPNSV EAAAQQTWQA RDAYLVHEHA KNPDGSEKPK FYACSMLPYP    50
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK 100
VPPAKWTYDN IAYMKKQMKA MGLAIDWSRE MCACDPKYYK WNQWLFLKML 150
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGAPVE KREIPGYYLR 200
ITDYAEELLD QVSTNLPGWP ERVRLMQENW IGKSEGLRFA FPHRIAGADG 250
KLIQDGKLYV FTTRADTIMG VTFCAVAPEH PLATHAAQSN PALAAFVEQC 300
KLGGTTEAEM ATREKEGMPT GLTVTHPLTG AEIDVWVGNY VLMTYGDGAV 350
MGVPAHDERD FAFARKYGLP IRQVVALEGK TYSTDAWQEW YGDKQAGRTV 400
NSGKYDGLAY QAAVDTIAAD LAAQGLGEKQ TTWRLRDWGI SRQRYWGTPI 450
PIIHCADCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPRCG 500
KPARRETDTM DTFVDSSWYF MRYTSPDNDQ AMVDARNDYW MPMDQYIGGI 550
EHAVLHLLYA RFWTKVMRDL GLLNFDEPFT KLLCQGMVLN HIYSRKTPQG 600
GIEYFWPEEV DNVYDAKGAI VGAKLQRDGS EVNYGGVGTM SKSKNNGVDP 650
QSLIDTLGAD TARLFVMFAS PPEQTLEWSD SGVEGANRFL RRLWALGYAQ 700
REAVGRGLAT GADWAQAPAP VKELRREVYG LLKQADYDYQ RIQYNTVVSA 750
CMKMLNAIDD APLPEGPAAD AARAETLGLL LRVLYPVVPH ITWHLWQDLG 800
YAEHLGDLLD APWPHVDEAA LVADEIELML QVNGKLRGSI RVAAKAPKED 850
IERIAAAQEE VARFLEGRPP KRVIVVPGKL VNVVG 885
Length:885
Mass (Da):99,008
Last modified:October 1, 2003 - v1
Checksum:iCA58CA2663A754DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640447 Genomic DNA. Translation: CAE33869.1.
RefSeqiNP_889911.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33869; CAE33869; BB3377.
GeneIDi2659654.
KEGGibbr:BB3377.
PATRICi21140169. VBIBorBro124907_3449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640447 Genomic DNA. Translation: CAE33869.1 .
RefSeqi NP_889911.1. NC_002927.3.

3D structure databases

ProteinModelPortali Q7WH33.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257310.BB3377.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE33869 ; CAE33869 ; BB3377 .
GeneIDi 2659654.
KEGGi bbr:BB3377.
PATRICi 21140169. VBIBorBro124907_3449.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BBRO257310:BB3377-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiSYL_BORBR
AccessioniPrimary (citable) accession number: Q7WH33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi