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Protein

Ubiquinone biosynthesis O-methyltransferase

Gene

ubiG

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L-homocysteine + ubiquinone-n.UniRule annotation
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol = S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol.UniRule annotation

Pathwayi: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46S-adenosyl-L-methionineUniRule annotation1
Binding sitei66S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1
Binding sitei87S-adenosyl-L-methionineUniRule annotation1
Binding sitei131S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquinone biosynthesis O-methyltransferaseUniRule annotation
Alternative name(s):
2-polyprenyl-6-hydroxyphenol methylaseUniRule annotation (EC:2.1.1.222UniRule annotation)
3-demethylubiquinone 3-O-methyltransferaseUniRule annotation (EC:2.1.1.64UniRule annotation)
Gene namesi
Name:ubiGUniRule annotation
Ordered Locus Names:BB3475
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001933681 – 241Ubiquinone biosynthesis O-methyltransferaseAdd BLAST241

Interactioni

Protein-protein interaction databases

STRINGi257310.BB3475.

Structurei

3D structure databases

ProteinModelPortaliQ7WGT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. UbiG/COQ3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OrthoDBiPOG091H064Z.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WGT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTATQSSAP GVNVDQAEVE KFSALAARWW DPESEFKPLH AINPLRLGWI
60 70 80 90 100
QETAGSLSGK RVLDVGCGGG ILSESMAVAG AQVTGIDLAE KSLKIARLHG
110 120 130 140 150
LESGVKVDYR AVPVEELATE QPGQYDVVTC MEMLEHVPDP ASVVRACAAL
160 170 180 190 200
AKPGGWVFFS TLNRNPKSFL FAIVGAEYVL RLLPRGTHSY DSFIKPSELA
210 220 230 240
ASARQAGLEP TGMRGMEYNP ITQVYSLSAN TSVNYLMSTR K
Length:241
Mass (Da):25,960
Last modified:December 15, 2003 - v2
Checksum:i96B5EEFB7D2F1A07
GO

Sequence cautioni

The sequence CAE33967 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640447 Genomic DNA. Translation: CAE33967.1. Different initiation.
RefSeqiWP_033451944.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33967; CAE33967; BB3475.
KEGGibbr:BB3475.
PATRICi21140379. VBIBorBro124907_3549.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640447 Genomic DNA. Translation: CAE33967.1. Different initiation.
RefSeqiWP_033451944.1. NC_002927.3.

3D structure databases

ProteinModelPortaliQ7WGT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB3475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE33967; CAE33967; BB3475.
KEGGibbr:BB3475.
PATRICi21140379. VBIBorBro124907_3549.

Phylogenomic databases

eggNOGiENOG4107RFD. Bacteria.
COG2227. LUCA.
HOGENOMiHOG000278065.
KOiK00568.
OrthoDBiPOG091H064Z.

Enzyme and pathway databases

UniPathwayiUPA00232.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00472. UbiG. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR010233. UbiG_MeTrfase.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01983. UbiG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUBIG_BORBR
AccessioniPrimary (citable) accession number: Q7WGT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.