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Q7WGH4 (MURB_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylenolpyruvoylglucosamine reductase

EC=1.1.1.158
Alternative name(s):
UDP-N-acetylmuramate dehydrogenase
Gene names
Name:murB
Ordered Locus Names:BB3945
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP MF_00037

Catalytic activity

UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037

Cofactor

FAD By similarity. HAMAP MF_00037

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037

Subcellular location

Cytoplasm By similarity HAMAP MF_00037.

Sequence similarities

Belongs to the MurB family.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037
PRO_0000179180

Regions

Domain31 – 201171FAD-binding PCMH-type

Sites

Active site1771 By similarity
Active site2501Proton donor By similarity
Active site3461 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WGH4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: FCC2DC94254236C7

FASTA35337,591
        10         20         30         40         50         60 
MSMSTVPARI EPVAPLAPQA QDLRCFNTLG LASHAPAFVA LTEPSQLPAL SALAPRFRQL 

        70         80         90        100        110        120 
VVLGGGSNVV LPASIDGLVA QVRLPGVRLV GQCADAWVVE AAAGENWHGF VTVCVDNGWD 

       130        140        150        160        170        180 
GLENLALIPG TVGAAPVQNI GAYGVELADR FHSLTAWDVK GGRWVEMGAA ECRFAYRDSF 

       190        200        210        220        230        240 
FKHQEPGAWV IGSVRFALPR PWQPVLDYPD LQRHAALDGA APTARAVYDA VCAIRRAKLP 

       250        260        270        280        290        300 
DPAVVGNAGS FFKNPLVDAG TRQALLGRFP GLVSYPQPDG RYKLAAGWLI DQCGWKGRQL 

       310        320        330        340        350 
GAAGVHDRQA LVLVNRGGAQ AHDIMALAAA IQGDVERRYG VRLEPEPVVV PAR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640449 Genomic DNA. Translation: CAE34308.1.
RefSeqNP_890479.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WGH4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2660802.
GenomeReviewsGene locus BB3945 in contig BX470250_GR.
KEGGbbr:BB3945.
NMPDRfig|257310.1.peg.3926.
PATRIC21141295. VBIBorBro124907_4005.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG686573.
OMALAYEITS.
PhylomeDBQ7WGH4.
ProtClustDBPRK00046.

Enzyme and pathway databases

BioCycBBRO257310:BB3945-MONOMER.

Family and domain databases

HAMAPMF_00037. MurB.
[Tree]
InterProIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
Gene3DG3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit.
G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit.
G3DSA:3.90.78.10. MurB_C. 1 hit.
KOK00075.
PANTHERPTHR21071. MurB. 1 hit.
PfamPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMSSF56176. FAD-binding_2. 1 hit.
SSF56194. MurB_C. 1 hit.
TIGRFAMsTIGR00179. MurB. 1 hit.
PROSITEPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMURB_BORBR
AccessionPrimary (citable) accession number: Q7WGH4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families