Reviewed, UniProtKB/Swiss-Prot Q7WFS8 (LPXC_BORBR)

Names and origin

Protein names

Recommended name:
    UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
    EC=3.5.1.-
Alternative name(s):
    UDP-3-O-acyl-GlcNAc deacetylase

Gene names

Name:	lpxC
Ordered Locus Names:	BB4192

Organism

Bordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

518 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.
Catalytic activity	UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine + H2O = UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine + acetate. HAMAP MF_00388
Pathway	Glycolipid biosynthesis; lipid (IV)A biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-D-glucosamine: step 2/6. HAMAP MF_00388
Sequence similarities	Belongs to the lpxC family.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase HAMAP MF_00388		PRO_0000253647

Sequences

	Sequence		Length	Mass (Da)
	Q7WFS8-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C30D9FB015FD4856	FASTA	307	34,156
	10 20 30 40 50 60 MFRQRSIQNL VRTIGVGVHS GRRVELTLRP AEANTGIVFH RVDLPQVVDL PASAIGVGDT 70 80 90 100 110 120 RMASVLQQGN VRVSTVEHLM SALAGLGIDN LHVDLTAEEV PIMDGSAATF VYLLRSAGIV 130 140 150 160 170 180 EQNAPKRFIR VLKPIEVREG EGRNEKWARL EPHEGFALAF SIDFRHPAID STANFAEIDF 190 200 210 220 230 240 ATHSYVREIA RARTFGFVNE VEALRSMGLA RGGSLDNAIV MDEFRVLNSD GLRYDDEFVK 250 260 270 280 290 300 HKILDAIGDL YLLGKPLVAR YVAYKSGHAL NNQLARALLE QQDAWELVTY ESQAEAPQAF RHEWKLA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RB50 / ATCC BAA-588 / NCTC 13252.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX640449 Genomic DNA. Translation: CAE34556.1.
RefSeq	NP_890727.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2661983.
GenomeReviews	Gene locus BB4192 in contig BX470250_GR.
KEGG	bbr:BB4192.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q7WFS8.
OMA	Q7WFS8. TGVGVHS.
Enzyme and pathway databases
BioCyc	BBRO257310:BB4192-MON.
Family and domain databases
HAMAP	MF_00388. [Tree]
InterPro	IPR004463. UDP-acyl_GlcNac_deAcase. IPR011334. UDP-acyl_GlcNac_deAcase_C. IPR015870. UDP-acyl_N-AcGlcN_deAcase_N. [Graphical view]
Gene3D	G3DSA:3.30.1700.10. UDP-acyl_N-AcGlcN_deAcase_C. 1 hit. G3DSA:3.30.230.20. UDP-acyl_N-AcGlcN_deAcase_N. 1 hit.
Pfam	PF03331. LpxC. 1 hit. [Graphical view]
ProDom	PD011499. Lipid_A_LpxC. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00325. lpxC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LPXC_BORBR

Accession

Primary (citable) accession number: Q7WFS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	October 1, 2003
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)