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Q7WFS0 (MURD_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
EC=6.3.2.9
Alternative name(s):
D-glutamic acid-adding enzyme
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Gene names
Name:murD
Ordered Locus Names:BB4200
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639

Subcellular location

Cytoplasm By similarity HAMAP MF_00639.

Sequence similarities

Belongs to the MurCDEF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639
PRO_0000108976

Regions

Nucleotide binding138 – 1447ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q7WFS0 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 6CDBB564A1B57FFA

FASTA51054,006
        10         20         30         40         50         60 
MNTTETSRAA APLVLILGLG ETGVAAARWC ARQGSPLRVA DTRAQPGGLA ALQAALADAT 

        70         80         90        100        110        120 
VEYRLGCGEQ FPPDLLDGVA QIVLSPGLVP HESPTRELLE QARERNVEVV GEIELFARAL 

       130        140        150        160        170        180 
AGLAESREYR PRVLAITGTN GKTTVTALTR QLIEAGGMSA RAAGNISPAA LAALIDALDQ 

       190        200        210        220        230        240 
DDLPQVWVLE LSSFQLETTR TLAPDAAVVL NVTQDHLDWH GDMQAYAQAK ARILKPARLA 

       250        260        270        280        290        300 
IVNRDDPLTV AMVESLQALN VRSFGRDVPA LVGDMGLELG QGVAWLTACE SNDFDEPAPA 

       310        320        330        340        350        360 
PRRKKDAPPP TRAGGRMSRL MPVDALRIRG VHNALNALAA MQLARSLDLG WGPMLRTLRD 

       370        380        390        400        410        420 
YAGEPHRAEL VRSIGDVDYI NDSKGTNVGA TVAALEGLGQ QVVLIAGGQG KGQDFSPLVP 

       430        440        450        460        470        480 
VVRRHARAVV LIGVDGAAIG KVLEPTGVPC VAAADMREAV RRAAELAQPG DAVLLSPACA 

       490        500        510 
SFDMFRNYPH RGEVFAAEVQ ELALDRGEVA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640449 Genomic DNA. Translation: CAE34564.1.
RefSeqNP_890735.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WFS0.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2661413.
GenomeReviewsGene locus BB4200 in contig BX470250_GR.
KEGGbbr:BB4200.
NMPDRfig|257310.1.peg.4182.
PATRIC21141827. VBIBorBro124907_4266.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG750024.
OMAACASWDM.
PhylomeDBQ7WFS0.
ProtClustDBPRK02006.

Enzyme and pathway databases

BioCycBBRO257310:BB4200-MONOMER.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR018109. Folylpolyglutamate_synth_CS.
IPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURD_BORBR
AccessionPrimary (citable) accession number: Q7WFS0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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