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Q7WFR9

- MRAY_BORBR

UniProt

Q7WFR9 - MRAY_BORBR

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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. cell wall organization Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBBRO257310:BB4201-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BB4201
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_0000108789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257310.BB4201.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalUniRule annotationAdd
BLAST
Transmembranei59 – 7921HelicalUniRule annotationAdd
BLAST
Transmembranei85 – 10521HelicalUniRule annotationAdd
BLAST
Transmembranei122 – 14221HelicalUniRule annotationAdd
BLAST
Transmembranei155 – 17521HelicalUniRule annotationAdd
BLAST
Transmembranei178 – 19821HelicalUniRule annotationAdd
BLAST
Transmembranei210 – 23021HelicalUniRule annotationAdd
BLAST
Transmembranei247 – 26721HelicalUniRule annotationAdd
BLAST
Transmembranei274 – 29421HelicalUniRule annotationAdd
BLAST
Transmembranei299 – 31921HelicalUniRule annotationAdd
BLAST
Transmembranei354 – 37421HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
HOGENOMiHOG000275122.
KOiK01000.
OMAiIFKRRIF.
OrthoDBiEOG69GZPZ.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WFR9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAIGVFEYI TLRAVLACAT ALLIGLVAGP RVIRRLTEMK IGQAVRAYGP
60 70 80 90 100
ESHLVKTGTP TMGGALILIA IAISTLLWAD WTNRFVWVVL LVTFGFGWIG
110 120 130 140 150
WMDDYRKVVY RDPEGMPARQ KFFWQATIGL VAAVYLAFAV SAPANTELWP
160 170 180 190 200
LFKAWVGSGF TMPLPTRADL IVPFFKSVSY PLGVLGFVAL TWAVIVGTSN
210 220 230 240 250
AVNLTDGLDG LAIMPTVMVG SALGIFAYVV GRVDYSKYLL FPYIPGAAEL
260 270 280 290 300
MVLCAAIGGA GLAFLWFNAY PAQVFMGDVG ALALGGALGT IAVIVRQEIV
310 320 330 340 350
LFIMGGVFVV ETLSVMVQVT WFKYTKRKYG QGRRIFRMAP LHHHFEVGGW
360 370
KETQVVVRFW IITMMLVLVG LSTLKLR
Length:377
Mass (Da):41,315
Last modified:October 1, 2003 - v1
Checksum:i3440248BAD69BF1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640449 Genomic DNA. Translation: CAE34565.1.
RefSeqiNP_890736.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE34565; CAE34565; BB4201.
GeneIDi2660682.
KEGGibbr:BB4201.
PATRICi21141829. VBIBorBro124907_4267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640449 Genomic DNA. Translation: CAE34565.1 .
RefSeqi NP_890736.1. NC_002927.3.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257310.BB4201.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE34565 ; CAE34565 ; BB4201 .
GeneIDi 2660682.
KEGGi bbr:BB4201.
PATRICi 21141829. VBIBorBro124907_4267.

Phylogenomic databases

eggNOGi COG0472.
HOGENOMi HOG000275122.
KOi K01000.
OMAi IFKRRIF.
OrthoDBi EOG69GZPZ.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BBRO257310:BB4201-MONOMER.

Family and domain databases

HAMAPi MF_00038. MraY.
InterProi IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view ]
PANTHERi PTHR22926. PTHR22926. 1 hit.
Pfami PF00953. Glycos_transf_4. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00445. mraY. 1 hit.
PROSITEi PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiMRAY_BORBR
AccessioniPrimary (citable) accession number: Q7WFR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3