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Q7WFR9 (MRAY_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BB4201
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella ›

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_0000108789

Regions

Transmembrane9 – 2921Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane247 – 26721Helical; Potential
Transmembrane274 – 29421Helical; Potential
Transmembrane299 – 31921Helical; Potential
Transmembrane354 – 37421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q7WFR9 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 3440248BAD69BF1C

FASTA37741,315
        10         20         30         40         50         60 
MRAIGVFEYI TLRAVLACAT ALLIGLVAGP RVIRRLTEMK IGQAVRAYGP ESHLVKTGTP 

        70         80         90        100        110        120 
TMGGALILIA IAISTLLWAD WTNRFVWVVL LVTFGFGWIG WMDDYRKVVY RDPEGMPARQ 

       130        140        150        160        170        180 
KFFWQATIGL VAAVYLAFAV SAPANTELWP LFKAWVGSGF TMPLPTRADL IVPFFKSVSY 

       190        200        210        220        230        240 
PLGVLGFVAL TWAVIVGTSN AVNLTDGLDG LAIMPTVMVG SALGIFAYVV GRVDYSKYLL 

       250        260        270        280        290        300 
FPYIPGAAEL MVLCAAIGGA GLAFLWFNAY PAQVFMGDVG ALALGGALGT IAVIVRQEIV 

       310        320        330        340        350        360 
LFIMGGVFVV ETLSVMVQVT WFKYTKRKYG QGRRIFRMAP LHHHFEVGGW KETQVVVRFW 

       370 
IITMMLVLVG LSTLKLR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640449 Genomic DNA. Translation: CAE34565.1.
RefSeqNP_890736.1. NC_002927.3.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING257310.BB4201.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE34565; CAE34565; BB4201.
GeneID2660682.
KEGGbbr:BB4201.
PATRIC21141829. VBIBorBro124907_4267.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275122.
KOK01000.
OMARFWIVTM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycBBRO257310:BB4201-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BORBR
AccessionPrimary (citable) accession number: Q7WFR9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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