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Q7WF38 (GLPK_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase

EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:BB4442
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Glycerol kinase HAMAP MF_00186
PRO_0000059435

Regions

Nucleotide binding415 – 4195ATP By similarity

Sites

Binding site141Substrate By similarity
Binding site181ATP By similarity
Binding site841Substrate By similarity
Binding site1361Substrate By similarity
Binding site2451Substrate By similarity
Binding site2671ATP By similarity
Binding site3141ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WF38 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EF62A75C47196B48

FASTA50854,652
        10         20         30         40         50         60 
MTANEFILAL DQGTTSSRAI VFDRAGTVRG MGQREFRQHY PRPGWVEHDA GEIWQSQLEV 

        70         80         90        100        110        120 
AREALRNAGA SAADLAALGI TNQRETTLIW ERATGRPLAR AIVWQDRRTA AMCEKLLHDG 

       130        140        150        160        170        180 
HGRMLQERTG LVVDAYFSGT KLAWLLDHVP GARKMAERGE LAFGTVDTWL VWQLTGGAVH 

       190        200        210        220        230        240 
STDPSNASRT MLFDLHAQDW SDDILALLNI PRGILPRIAP SSARIGETLP EWLGGSIPIA 

       250        260        270        280        290        300 
GVAGDQQAAT FGQACFTPGM AKNTYGTGCF MLMNVGDAPV ASRHNLLSTV GWSLPAGNAT 

       310        320        330        340        350        360 
HATYMVEGGV FMAGAAVQWL RDGLGIIQRS ADIEALAASV ADTDDVFMVP AFAGLGAPHW 

       370        380        390        400        410        420 
DPYARGTLVG MTRGTTRAHI ARATLESIAL QSAELLSCMN ADSGIPLSEL RVDGGAARND 

       430        440        450        460        470        480 
LLMQMQADLL GVPVVRPRVP ESTALGAAGL AGLAVGFWSS LDEFGAQWQA ERTFEPAWPA 

       490        500 
DVREARMQRW RQAVELSKGW SRPAAGHA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640450 Genomic DNA. Translation: CAE34805.1.
RefSeqNP_890976.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WF38.
SMRQ7WF38. Positions 6-502.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2661068.
GenomeReviewsGene locus BB4442 in contig BX470250_GR.
KEGGbbr:BB4442.
PATRIC21142347. VBIBorBro124907_4519.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG511469.
OMAATYFSGT.
PhylomeDBQ7WF38.
ProtClustDBPRK00047.

Enzyme and pathway databases

BioCycBBRO257310:BB4442-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_BORBR
AccessionPrimary (citable) accession number: Q7WF38
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families