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Q7WEU9 (PYRE_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10
Gene names
Name:pyrE
Ordered Locus Names:BB4533
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208

Subunit structure

Homodimer By similarity. HAMAP MF_01208

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Sequence caution

The sequence CAE34896.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMagnesium
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

pyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionorotate phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Orotate phosphoribosyltransferase HAMAP MF_01208
PRO_0000110675

Regions

Region37 – 382Orotate binding By similarity
Region75 – 7625-phosphoribose 1-diphosphate binding By similarity
Region130 – 13895-phosphoribose 1-diphosphate binding By similarity

Sites

Binding site2915-phosphoribose 1-diphosphate By similarity
Binding site10515-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site10615-phosphoribose 1-diphosphate By similarity
Binding site10915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site11115-phosphoribose 1-diphosphate; shared with dimeric partner By similarity
Binding site1341Orotate By similarity
Binding site1621Orotate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WEU9 [UniParc].

Last modified January 16, 2004. Version 2.
Checksum: F0AED7CD4006ED2E

FASTA22423,428
        10         20         30         40         50         60 
MSASASTAAD FVRFALDEGV LRFGSFKVKS GRISPYFFNA GLFNSGRSVG ALAGFYAQAL 

        70         80         90        100        110        120 
VDSGVAFDML FGPAYKGIPL ATATSVALAG HRAMAGRDVP FAFNRKEAKD HGEGGTLVGA 

       130        140        150        160        170        180 
PLTGKVVIID DVITAGTSVR ESVEIIRAAG AEPAAVLIAL DRMERAGPDD ALSPHSAVQD 

       190        200        210        220 
VARTYGIPVV SIASLADIMT LLQDDAQFAE HREAVQAYRS KYGV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640450 Genomic DNA. Translation: CAE34896.1. Different initiation.

3D structure databases

ProteinModelPortalQ7WEU9.
SMRQ7WEU9. Positions 8-224.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GenomeReviewsGene locus BB4533 in contig BX470250_GR.
KEGGbbr:BB4533.
NMPDRfig|257310.1.peg.4514.
PATRIC21142538. VBIBorBro124907_4614.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
PhylomeDBQ7WEU9.
ProtClustDBPRK00455.

Enzyme and pathway databases

BioCycBBRO257310:BB4533-MONOMER.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRE_BORBR
AccessionPrimary (citable) accession number: Q7WEU9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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