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Protein

Homoserine O-succinyltransferase

Gene

metXS

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.UniRule annotation

Catalytic activityi

Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-succinyltransferase (metXS)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-succinyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei175NucleophileUniRule annotation1
Binding sitei245SubstrateUniRule annotation1
Active sitei344UniRule annotation1
Sitei346Important for acyl-CoA specificityUniRule annotation1
Active sitei377UniRule annotation1
Binding sitei378SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00051; UER00075.

Protein family/group databases

ESTHERiborpe-METX. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-succinyltransferaseUniRule annotation (EC:2.3.1.46UniRule annotation)
Short name:
HSTUniRule annotation
Alternative name(s):
Homoserine transsuccinylaseUniRule annotation
Short name:
HTSUniRule annotation
Gene namesi
Name:metXSUniRule annotation
Ordered Locus Names:BB4554
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001557041 – 415Homoserine O-succinyltransferaseAdd BLAST415

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257310.BB4554.

Structurei

3D structure databases

ProteinModelPortaliQ7WES8.
SMRiQ7WES8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 383AB hydrolase-1UniRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MetX family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiCQGTTGP.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. MetX_acyltransf. 1 hit.
InterProiView protein in InterPro
IPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoser/ser_AcTrfase.
IPR034387. Homoser_AcTrfase.
PfamiView protein in Pfam
PF00561. Abhydrolase_1. 1 hit.
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WES8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPVLNPAL PATAAAPVAA TPSAVGSAGI VAPVFLRFDE PLPLASGQTL
60 70 80 90 100
DGYELAIETY GTLNAQRTNA VLVCHALNAS HHVAGVSADN PKDVGWWDNM
110 120 130 140 150
VGPGKPVDTN RYFVIGVNNL GSCFGSTGPA SINPATGRPW GAAFPVLTVE
160 170 180 190 200
DWVRAQARVA DHFGIERFAA VMGGSLGGMQ ALSWAITCPQ RVANCVVVAS
210 220 230 240 250
TPRLSAQNIG FNEVARRAII TDPDFHGGDY YAHGTVPGRG LSVARMIGHI
260 270 280 290 300
TYLSDDDMAE KFGRTRREPA ADGAYRYGYD VEFEVESYLR YQGEKFSRYF
310 320 330 340 350
DANTYLLITR ALDYFDPARA TGGDLARALA PATADFLLVS FSTDWRFPPE
360 370 380 390 400
RSREMVRALL KNGSPVTYAE IDAPHGHDAF LLDDARYHAV VRGYYERIAR
410
ELGLNGAVAP EGNPA
Length:415
Mass (Da):44,685
Last modified:October 1, 2003 - v1
Checksum:i3C2121127F2E2F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640450 Genomic DNA. Translation: CAE34917.1.
RefSeqiWP_003815253.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE34917; CAE34917; BB4554.
KEGGibbr:BB4554.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMETXS_BORBR
AccessioniPrimary (citable) accession number: Q7WES8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families