Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homoserine O-acetyltransferase

Gene

metX

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the methionine biosynthesis. Catalyzes the transfer of the acetyl group from acetyl-CoA to the hydroxyl group of L-homoserine to yield O-acetyl-L-homoserine.UniRule annotation

Catalytic activityi

Acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine.UniRule annotation

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Homoserine O-acetyltransferase (metX)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes O-acetyl-L-homoserine from L-homoserine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei175 – 1751NucleophileUniRule annotation
Active sitei344 – 3441UniRule annotation
Active sitei377 – 3771UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Methionine biosynthesis

Enzyme and pathway databases

BioCyciBBRO257310:BB4554-MONOMER.
UniPathwayiUPA00051; UER00074.

Protein family/group databases

ESTHERiborpe-METX. Homoserine_transacetylase.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine O-acetyltransferaseUniRule annotation (EC:2.3.1.31UniRule annotation)
Alternative name(s):
Homoserine O-trans-acetylaseUniRule annotation
Short name:
HTAUniRule annotation
Short name:
Homoserine transacetylaseUniRule annotation
Gene namesi
Name:metXUniRule annotation
Ordered Locus Names:BB4554
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Homoserine O-acetyltransferasePRO_0000155704Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi257310.BB4554.

Structurei

3D structure databases

ProteinModelPortaliQ7WES8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. HTA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WES8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPVLNPAL PATAAAPVAA TPSAVGSAGI VAPVFLRFDE PLPLASGQTL
60 70 80 90 100
DGYELAIETY GTLNAQRTNA VLVCHALNAS HHVAGVSADN PKDVGWWDNM
110 120 130 140 150
VGPGKPVDTN RYFVIGVNNL GSCFGSTGPA SINPATGRPW GAAFPVLTVE
160 170 180 190 200
DWVRAQARVA DHFGIERFAA VMGGSLGGMQ ALSWAITCPQ RVANCVVVAS
210 220 230 240 250
TPRLSAQNIG FNEVARRAII TDPDFHGGDY YAHGTVPGRG LSVARMIGHI
260 270 280 290 300
TYLSDDDMAE KFGRTRREPA ADGAYRYGYD VEFEVESYLR YQGEKFSRYF
310 320 330 340 350
DANTYLLITR ALDYFDPARA TGGDLARALA PATADFLLVS FSTDWRFPPE
360 370 380 390 400
RSREMVRALL KNGSPVTYAE IDAPHGHDAF LLDDARYHAV VRGYYERIAR
410
ELGLNGAVAP EGNPA
Length:415
Mass (Da):44,685
Last modified:October 1, 2003 - v1
Checksum:i3C2121127F2E2F1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640450 Genomic DNA. Translation: CAE34917.1.
RefSeqiWP_003815253.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE34917; CAE34917; BB4554.
KEGGibbr:BB4554.
PATRICi21142582. VBIBorBro124907_4636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640450 Genomic DNA. Translation: CAE34917.1.
RefSeqiWP_003815253.1. NC_002927.3.

3D structure databases

ProteinModelPortaliQ7WES8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB4554.

Protein family/group databases

ESTHERiborpe-METX. Homoserine_transacetylase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE34917; CAE34917; BB4554.
KEGGibbr:BB4554.
PATRICi21142582. VBIBorBro124907_4636.

Phylogenomic databases

eggNOGiENOG4105DWV. Bacteria.
COG2021. LUCA.
HOGENOMiHOG000246301.
KOiK00641.
OMAiGSVGGMN.
OrthoDBiPOG091H08NY.

Enzyme and pathway databases

UniPathwayiUPA00051; UER00074.
BioCyciBBRO257310:BB4554-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_00296. Homoser_O_acetyltr. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR008220. Homoserine_AcTrfase.
[Graphical view]
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000443. Homoser_Ac_trans. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01392. homoserO_Ac_trn. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMETX_BORBR
AccessioniPrimary (citable) accession number: Q7WES8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.