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Q7WEN2 (DCUP_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:BB4602
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm Probable HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000187585

Regions

Region29 – 335Substrate binding By similarity

Sites

Binding site481Substrate By similarity
Binding site791Substrate By similarity
Binding site1551Substrate By similarity
Binding site2101Substrate By similarity
Binding site3301Substrate By similarity
Site791Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WEN2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F3D6556CFD508FF5

FASTA35839,298
        10         20         30         40         50         60 
MSVAPLKNDV FLRALLREPV PYTPIWLMRQ AGRYLPEYNA TRARAGSFMG LAQNPDYACE 

        70         80         90        100        110        120 
VTLQPLARYP LDAAILFSDI LTVPHAMGLG LDFAPGEGPR FAHPVRDESD VAKLAVPDMD 

       130        140        150        160        170        180 
SLRYVFDAVR TIRRELDGRV PLIGFAGSPW TIACYMVEGR GSDDYRLIKS MLYGRPDLLH 

       190        200        210        220        230        240 
RILEINAEAT RHYLNAQIDA GAQAVMLFDS WGGVLADGLF QQFSLAYTRR VVEGLTRERE 

       250        260        270        280        290        300 
GRRVPVIVFT KGGGQWLEEI AACGCDAVGL DWTVNLGTAR RRVADAVALQ GNLDPMTLFG 

       310        320        330        340        350 
GAQAVRAEAR RTLDAFGPVG KGGHVFNLGH GISQYSPPEV VSELVDEVHT YSRALHAG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640451 Genomic DNA. Translation: CAE34964.1.
RefSeqNP_891134.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WEN2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2662137.
GenomeReviewsGene locus BB4602 in contig BX470250_GR.
KEGGbbr:BB4602.
NMPDRfig|257310.1.peg.4581.
PATRIC21142683. VBIBorBro124907_4685.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ7WEN2.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycBBRO257310:BB4602-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_BORBR
AccessionPrimary (citable) accession number: Q7WEN2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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