Q7WEL4 (DSBC_BORBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable thiol:disulfide interchange protein DsbC

Gene names

Name:	dsbC
Ordered Locus Names:	BB4620

Organism

Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]

Taxonomic identifier

257310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 279	248	Probable thiol:disulfide interchange protein DsbC		PRO_0000245643
Amino acid modifications
	Disulfide bond	174 ↔ 177		Redox-active By similarity
	Disulfide bond	213 ↔ 236		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7WEL4 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 367CD6DC9DDCCDD1	FASTA	279	30,683
	10 20 30 40 50 60 MSGPPFSGAG MNFRITVWCA AAAVWSSGAL AQDGAGQAAP GTPDKVYSTT GTAPAKPGDK 70 80 90 100 110 120 VYSTRSAQAP DPQADAVKER FAQRFEGFDV TAVRRTPYGL FEVQIGTDLL YTDEKVTWVM 130 140 150 160 170 180 EGPLIDALTR RDVTRERQEK LSSVPFDELP LDLAVKQVKG DGSRVMAVFE DPNCGYCKQL 190 200 210 220 230 240 HRTLEDMDNI TVYTFLYPIL SPDSTTKVRD IWCASDPAKV WKDWMVRGQR PPTAECDAPV 250 260 270 EQWLALGRQL MVRGTPAIFF KSGGRVSGAL PRDELEARL

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640451 Genomic DNA. Translation: CAE34982.1.
RefSeq	NP_891152.1. NC_002927.3.
3D structure databases
ProteinModelPortal	Q7WEL4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2659018.
GenomeReviews	Gene locus BB4620 in contig BX470250_GR.
KEGG	bbr:BB4620.
PATRIC	21142721. VBIBorBro124907_4704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG469935.
OMA	GLYEVKL.
PhylomeDB	Q7WEL4.
ProtClustDB	CLSK921008.
Enzyme and pathway databases
BioCyc	BBRO257310:BB4620-MONOMER.
Family and domain databases
InterPro	IPR018950. DiS-bond_isomerase_DsbC/G_N. IPR009094. DiS-bond_isomerase_DsbC_N. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03981.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_BORBR

Accession

Primary (citable) accession number: Q7WEL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program