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Q7WE57 (ASPD3_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase 3

EC=1.4.1.21
Gene names
Name:nadX3
Ordered Locus Names:BB4781
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Probable L-aspartate dehydrogenase 3 HAMAP-Rule MF_01265
PRO_0000144882

Sites

Active site2241 By similarity
Binding site1261NAD; via amide nitrogen By similarity
Binding site1941NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WE57 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 886F834DB20755BD

FASTA27228,270
        10         20         30         40         50         60 
MSSREELGVA VAGLGAIGKA LANRLARNEV AGCRLSAVSG RDPGRTADFI ASLPRPVPAV 

        70         80         90        100        110        120 
PLHELPRHAD IVVECAPAAV LPQIVEPVLD AGKKVIVLSV GALLEFPELF RKAGSSDGQI 

       130        140        150        160        170        180 
LVPTGALLGL DAVTAAAEGR IESVKMVSRK PPIGFKGAPI LAERNLDIDG LTEPLLLYSG 

       190        200        210        220        230        240 
SARAAARGFP ANLNVAVALS LAGIGPDETQ LEVWADPGVV RNTHTIEVVS DAALLRMTIE 

       250        260        270 
NIPSENPKTG RITAQSVMAM LRKMSAPVRV GT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640451 Genomic DNA. Translation: CAE35144.1.
RefSeqNP_891314.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WE57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257310.BB4781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE35144; CAE35144; BB4781.
GeneID2659376.
KEGGbbr:BB4781.
PATRIC21143052. VBIBorBro124907_4869.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMAFHAKIEN.
OrthoDBEOG6VTK2D.

Enzyme and pathway databases

BioCycBBRO257310:BB4781-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD3_BORBR
AccessionPrimary (citable) accession number: Q7WE57
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways