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Q7WDY4 (HISX_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase

Short name=HDH
EC=1.1.1.23
Gene names
Name:hisD
Ordered Locus Names:BB4854
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. HAMAP-Rule MF_01024

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. HAMAP-Rule MF_01024

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01024

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. HAMAP-Rule MF_01024

Sequence similarities

Belongs to the histidinol dehydrogenase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: InterPro

histidinol dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 440440Histidinol dehydrogenase HAMAP-Rule MF_01024
PRO_0000135736

Sites

Active site3361Proton acceptor By similarity
Active site3371Proton acceptor By similarity
Metal binding2681Zinc By similarity
Metal binding2711Zinc By similarity
Metal binding3701Zinc By similarity
Metal binding4291Zinc By similarity
Binding site1391NAD By similarity
Binding site2001NAD By similarity
Binding site2231NAD By similarity
Binding site2461Substrate By similarity
Binding site2681Substrate By similarity
Binding site2711Substrate By similarity
Binding site3371Substrate By similarity
Binding site3701Substrate By similarity
Binding site4241Substrate By similarity
Binding site4291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WDY4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: D8FC76AF462F129A

FASTA44046,882
        10         20         30         40         50         60 
MQYHDAMALI NRLDSRDPGF KTALSQLLAF EAEQDESIDQ AAAGILADVR RRGDAALLEY 

        70         80         90        100        110        120 
TQRFDRLAVD DATALEIPQA DWHAALDSLP AAQRQALEAA AARVRAYHER QRGETWTYTE 

       130        140        150        160        170        180 
ADGTMLGQQI TALDRVGLYV PGGKAAYPSS VLMNAIPAKV AGVPELIMVT PTPDGVRNPI 

       190        200        210        220        230        240 
VLAAAAIAGV DRAFAIGGAQ AVGALAYGTA TVPAVDKIVG PGNAYVAAAK RRVFGTVGID 

       250        260        270        280        290        300 
MIAGPSEILV ICDGKTPADW IAMDLFSQAE HDELAQSILL CPDAAFLAEV EAAIERLLPG 

       310        320        330        340        350        360 
MPRADILRVS LANRGALILV RDLEEACAIA NDIAPEHLEI STEQPQRWTA LIRHAGAIFM 

       370        380        390        400        410        420 
GRYSSEALGD YCAGPNHVLP TSRTARFSSP LGVYDFQKRS SLIQVSREGA QTLGRIAAEL 

       430        440 
ALGEGLQAHA ASAQYRLDQP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640451 Genomic DNA. Translation: CAE35217.1.
RefSeqNP_891387.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WDY4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257310.BB4854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE35217; CAE35217; BB4854.
GeneID2659705.
KEGGbbr:BB4854.
PATRIC21143202. VBIBorBro124907_4944.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0141.
HOGENOMHOG000243914.
KOK00013.
OMAQKSLHAV.
OrthoDBEOG6CVVCR.

Enzyme and pathway databases

BioCycBBRO257310:BB4854-MONOMER.
UniPathwayUPA00031; UER00014.

Family and domain databases

HAMAPMF_01024. HisD.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHISX_BORBR
AccessionPrimary (citable) accession number: Q7WDY4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways