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Q7WDY4

- HISX_BORBR

UniProt

Q7WDY4 - HISX_BORBR

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Protein
Histidinol dehydrogenase
Gene
hisD, BB4854
Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391NAD By similarity
Binding sitei200 – 2001NAD By similarity
Binding sitei223 – 2231NAD By similarity
Binding sitei246 – 2461Substrate By similarity
Metal bindingi268 – 2681Zinc By similarity
Binding sitei268 – 2681Substrate By similarity
Metal bindingi271 – 2711Zinc By similarity
Binding sitei271 – 2711Substrate By similarity
Active sitei336 – 3361Proton acceptor By similarity
Active sitei337 – 3371Proton acceptor By similarity
Binding sitei337 – 3371Substrate By similarity
Metal bindingi370 – 3701Zinc By similarity
Binding sitei370 – 3701Substrate By similarity
Binding sitei424 – 4241Substrate By similarity
Metal bindingi429 – 4291Zinc By similarity
Binding sitei429 – 4291Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciBBRO257310:BB4854-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:BB4854
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Histidinol dehydrogenaseUniRule annotation
PRO_0000135736Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257310.BB4854.

Structurei

3D structure databases

ProteinModelPortaliQ7WDY4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiQKSLHAV.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WDY4-1 [UniParc]FASTAAdd to Basket

« Hide

MQYHDAMALI NRLDSRDPGF KTALSQLLAF EAEQDESIDQ AAAGILADVR    50
RRGDAALLEY TQRFDRLAVD DATALEIPQA DWHAALDSLP AAQRQALEAA 100
AARVRAYHER QRGETWTYTE ADGTMLGQQI TALDRVGLYV PGGKAAYPSS 150
VLMNAIPAKV AGVPELIMVT PTPDGVRNPI VLAAAAIAGV DRAFAIGGAQ 200
AVGALAYGTA TVPAVDKIVG PGNAYVAAAK RRVFGTVGID MIAGPSEILV 250
ICDGKTPADW IAMDLFSQAE HDELAQSILL CPDAAFLAEV EAAIERLLPG 300
MPRADILRVS LANRGALILV RDLEEACAIA NDIAPEHLEI STEQPQRWTA 350
LIRHAGAIFM GRYSSEALGD YCAGPNHVLP TSRTARFSSP LGVYDFQKRS 400
SLIQVSREGA QTLGRIAAEL ALGEGLQAHA ASAQYRLDQP 440
Length:440
Mass (Da):46,882
Last modified:October 1, 2003 - v1
Checksum:iD8FC76AF462F129A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640451 Genomic DNA. Translation: CAE35217.1.
RefSeqiNP_891387.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE35217; CAE35217; BB4854.
GeneIDi2659705.
KEGGibbr:BB4854.
PATRICi21143202. VBIBorBro124907_4944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640451 Genomic DNA. Translation: CAE35217.1 .
RefSeqi NP_891387.1. NC_002927.3.

3D structure databases

ProteinModelPortali Q7WDY4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 257310.BB4854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE35217 ; CAE35217 ; BB4854 .
GeneIDi 2659705.
KEGGi bbr:BB4854.
PATRICi 21143202. VBIBorBro124907_4944.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi QKSLHAV.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci BBRO257310:BB4854-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiHISX_BORBR
AccessioniPrimary (citable) accession number: Q7WDY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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