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Q7WDL7 (RIBB_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3,4-dihydroxy-2-butanone 4-phosphate synthase
Short name=DHBP synthase
EC=4.1.99.12
Gene names
Name:ribB
Ordered Locus Names:BB4971
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate By similarity. HAMAP MF_00180

Catalytic activity

D-ribulose 5-phosphate = formate + L-3,4-dihydroxybutan-2-one 4-phosphate. HAMAP MF_00180

Cofactor

Binds 2 divalent metal cations per subunit. Magnesium or manganese By similarity.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1. HAMAP MF_00180

Subunit structure

Homodimer By similarity. HAMAP MF_00180

Sequence similarities

Belongs to the DHBP synthase family.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processriboflavin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3,4-dihydroxy-2-butanone-4-phosphate synthase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2302303,4-dihydroxy-2-butanone 4-phosphate synthase HAMAP MF_00180
PRO_0000151788

Regions

Region42 – 432Substrate binding By similarity
Region155 – 1595Substrate binding By similarity

Sites

Metal binding431Magnesium or manganese 1 By similarity
Metal binding431Magnesium or manganese 2 By similarity
Metal binding1581Magnesium or manganese 2 By similarity
Binding site471Substrate By similarity
Binding site1791Substrate By similarity
Site1411Essential for catalytic activity By similarity
Site1791Essential for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7WDL7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 976E0451584FDB42

FASTA23024,125
        10         20         30         40         50         60 
MSNVVPTPVS PLFAQPFATR LERALQHLRI GRPVILMDDF DRENEADLIV AADKLTVPVM 

        70         80         90        100        110        120 
AQLIRDGSGI VCLCLPGETL DRLELPPMVD SNRSRYSTAF TVSIEAREGV TTGVSAVDRV 

       130        140        150        160        170        180 
TTIRAAIAPG ARSGDVVSPG HVFPLRAQPG GVLTRRGHTE GSVDLAALAG LRPAGVLCEL 

       190        200        210        220        230 
MNADGTMMRG ASLERYAAKE GLVALAIDEL AAHLQARGAT GAPAELAVAA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640452 Genomic DNA. Translation: CAE35335.1.
RefSeqNP_891505.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WDL7.
SMRQ7WDL7. Positions 14-217.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2663923.
GenomeReviewsGene locus BB4971 in contig BX470250_GR.
KEGGbbr:BB4971.
PATRIC21143450. VBIBorBro124907_5066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG735778.
OMAGDMIFAA.
PhylomeDBQ7WDL7.
ProtClustDBPRK00014.

Enzyme and pathway databases

BioCycBBRO257310:BB4971-MONOMER.

Family and domain databases

HAMAPMF_00180. RibB.
[Tree]
InterProIPR017945. DHBP_synth_RibB-like_a/b_dom.
IPR000422. DHBP_synthase_RibB.
[Graphical view]
Gene3DG3DSA:3.90.870.10. DHBP_synth_RibB-like_a/b_dom. 1 hit.
KOK02858.
PfamPF00926. DHBP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55821. DHBP_synth_RibB-like_a/b_dom. 1 hit.
TIGRFAMsTIGR00506. RibB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRIBB_BORBR
AccessionPrimary (citable) accession number: Q7WDL7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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