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Q7WCZ8

- PNCB_BORBR

UniProt

Q7WCZ8 - PNCB_BORBR

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciBBRO257310:BB3780-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:BB3780
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001027: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Nicotinate phosphoribosyltransferasePRO_0000205818Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257310.BB3780.

Structurei

3D structure databases

ProteinModelPortaliQ7WCZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7WCZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVCRNVSRQQ FRAIMIITSL LDTDLYKFSM MQVVLHHFPA AQVEYRYKCR
60 70 80 90 100
TPGINLRPYL DEIRAEVHEL CQLRFTSEEL DYLRGLRFIK SDFVDFLGLF
110 120 130 140 150
HLPERCIFIG EGEQPGEISI TVKGPWLHTI LFEIPVLAIV NEVYFRNTRR
160 170 180 190 200
NPDWEEGRKR LQSKMNLVLD DPALADFRVA EYGTRRRFSK VWHEEIVSTM
210 220 230 240 250
KARMGVHFAG TSNVLLAMRH GVLPLGTMGH EYLQACQALG PRLRDSQVFA
260 270 280 290 300
LEVWAKEYRG DLGIALSDVY GMDAFLRDFD MYFCKLFDGA RHDSGDPFVW
310 320 330 340 350
GERLLEHYRA NRADPRAKTL VFSDSLTFPR AIELARQFAG RCKVSFGIGT
360 370 380 390 400
NLTNDLGHEP LQIVMKMVRC NGQPVAKVSD APEKTMCDDP AYLAYLRQVF

QLPPA
Length:405
Mass (Da):46,627
Last modified:October 1, 2003 - v1
Checksum:i093CEDFB4FE82889
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640448 Genomic DNA. Translation: CAE35754.1.
RefSeqiNP_890315.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE35754; CAE35754; BB3780.
GeneIDi2659542.
KEGGibbr:BB3780.
PATRICi21140945. VBIBorBro124907_3833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640448 Genomic DNA. Translation: CAE35754.1 .
RefSeqi NP_890315.1. NC_002927.3.

3D structure databases

ProteinModelPortali Q7WCZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257310.BB3780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE35754 ; CAE35754 ; BB3780 .
GeneIDi 2659542.
KEGGi bbr:BB3780.
PATRICi 21140945. VBIBorBro124907_3833.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci BBRO257310:BB3780-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-588 / NCTC 13252 / RB50.

Entry informationi

Entry nameiPNCB_BORBR
AccessioniPrimary (citable) accession number: Q7WCZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3