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Q7WCP6 (ILVC_BORBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:BB3885
OrganismBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier257310 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase HAMAP MF_00435
PRO_0000151280

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
Q7WCP6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7A82A754B85DE794

FASTA33836,234
        10         20         30         40         50         60 
MKVFYDKDCD LSLVKGKTVA IIGYGSQGHA HALNLHDSGV KVVVGLRKGG ASWNKAANAG 

        70         80         90        100        110        120 
LEVAEVAEAV KRADIVMMLL PDENIAAVYR DEVHANIKAG AALAFAHGFN VHYGQVVPRE 

       130        140        150        160        170        180 
DIDVIMVAPK APGHTVRSTY SQGGGVPHLI AVYQDKSGSA RDVALSYASA NGGGRAGIIE 

       190        200        210        220        230        240 
TNFREETETD LFGEQAVLCG GTVELIKAGF DTLVEAGYAP EMAYFECLHE LKLIVDLIYE 

       250        260        270        280        290        300 
GGIANMNYSI SNNAEFGEYE TGPKVVTDAT RQAMRECLTA IQTGEYAKKF ILENAAGAPT 

       310        320        330 
LTSRRRINAE SQIEQVGGKL RAMMPWIAAN KLVDKAKN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640448 Genomic DNA. Translation: CAE35859.1.
RefSeqNP_890420.1. NC_002927.3.

3D structure databases

ProteinModelPortalQ7WCP6.
SMRQ7WCP6. Positions 1-327.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2663891.
GenomeReviewsGene locus BB3885 in contig BX470250_GR.
KEGGbbr:BB3885.
PATRIC21141167. VBIBorBro124907_3942.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG286525.
OMAMAYAKGI.
PhylomeDBQ7WCP6.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycBBRO257310:BB3885-MONOMER.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BORBR
AccessionPrimary (citable) accession number: Q7WCP6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families