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Reviewed, UniProtKB/Swiss-Prot Q7WCP6 (ILVC_BORBR)

Last modified November 25, 2008. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ketol-acid reductoisomerase
    EC=1.1.1.86
Alternative name(s):
    Acetohydroxy-acid isomeroreductase
    Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name: ilvC
Ordered Locus Names: BB3885
OrganismBordetella bronchiseptica (Alcaligenes bronchisepticus) [Complete proteome] [HAMAP]
Taxonomic identifier518 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ketol-acid reductoisomerase
PRO_0000151280

Sites

Active site1071 Potential

Sequences

Sequence LengthMass (Da)Tools
Q7WCP6-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7A82A754B85DE794

FASTA33836,234
        10         20         30         40         50         60 
MKVFYDKDCD LSLVKGKTVA IIGYGSQGHA HALNLHDSGV KVVVGLRKGG ASWNKAANAG 

        70         80         90        100        110        120 
LEVAEVAEAV KRADIVMMLL PDENIAAVYR DEVHANIKAG AALAFAHGFN VHYGQVVPRE 

       130        140        150        160        170        180 
DIDVIMVAPK APGHTVRSTY SQGGGVPHLI AVYQDKSGSA RDVALSYASA NGGGRAGIIE 

       190        200        210        220        230        240 
TNFREETETD LFGEQAVLCG GTVELIKAGF DTLVEAGYAP EMAYFECLHE LKLIVDLIYE 

       250        260        270        280        290        300 
GGIANMNYSI SNNAEFGEYE TGPKVVTDAT RQAMRECLTA IQTGEYAKKF ILENAAGAPT 

       310        320        330 
LTSRRRINAE SQIEQVGGKL RAMMPWIAAN KLVDKAKN 

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Cross-references

Sequence databases

BX640448 Genomic DNA. Translation: CAE35859.1.
RefSeqNP_890420.1.

3D structure databases

SMRQ7WCP6. Positions 1-327.
ModBaseSearch...

Genome annotation databases

GeneID2663891.
GenomeReviewsGene locus BB3885 in contig BX470250_GR.
KEGGbbr:BB3885.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ7WCP6.

Enzyme and pathway databases

BioCycBBRO257310:BB3885-MON.

Family and domain databases

HAMAPMF_00435.
[Tree]
InterProIPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013116. IlvN.
IPR016040. NAD(P)-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BORBR
AccessionPrimary (citable) accession number: Q7WCP6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: November 25, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents