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Q7WAK8

- PCKG_BORPA

UniProt

Q7WAK8 - PCKG_BORPA

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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene
pckG, pck, BPP1368
Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate By similarity
Binding sitei226 – 2261Substrate; via amide nitrogen By similarity
Metal bindingi233 – 2331Manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi253 – 2531Manganese; via tele nitrogen By similarity
Binding sitei275 – 2751Substrate By similarity
Active sitei277 – 2771 By similarity
Metal bindingi302 – 3021Manganese By similarity
Binding sitei398 – 3981GTP By similarity
Binding sitei429 – 4291GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816GTP By similarity
Nucleotide bindingi526 – 5294GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBPAR257311:BPP1368-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Synonyms:pck
Ordered Locus Names:BPP1368
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001421: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 618618Phosphoenolpyruvate carboxykinase [GTP]UniRule annotationPRO_0000103591Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi257311.BPP1368.

Structurei

3D structure databases

ProteinModelPortaliQ7WAK8.
SMRiQ7WAK8. Positions 17-617.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni396 – 3983Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WAK8-1 [UniParc]FASTAAdd to Basket

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MNKPSEVKPV ALNVPDYVKH SGLIAWVERI AALTKPDRVV WCDGSQEEYD    50
RLCEQMVQGG TMRRLNPAKR ANSYLACSDP SDVARVEDRT FICSEREEDA 100
GPTNNWAAPQ AMRETLGGLF DGAMRGRTMY VVPFSMGPLG SPIAHIGVEL 150
SDSPYVVVNM RIMTRMGRKV FDVLGSDGAF VPCVHSVGMP LAEGQQDVAW 200
PCNPTKYIVH YPETREIWSF GSGYGGNALL GKKCFALRIA STMGRDEGWL 250
AEHMLILGVT SPKGRKYHVA AAFPSACGKT NFAMLIPPHG MDGWKVTTIG 300
DDIAWIKPGP DGRLHAINPE AGYFGVAPGT SEKTNFNAMA MLKANVIFTN 350
VALTDDGDVW WEGMTDTPPA HLIDWQGQDW TPAIAAETGR KAAHPNARFT 400
APAAQCPSID PEWENPKGVA IDAFIFGGRR STTVPLVTEA RNWVEGVYMA 450
ATMGSETTAA AAGQQGVVRR DPFAMLPFCG YNMSDYFDHW LKLGRRLEET 500
GATLPRIYCV NWFRKGPDGK FVWPGFGENM RVLRWMLGRL DGQAGGVDQV 550
FGISPAYGDI DWTGLEFSPD KFEQVISVDL PAWRAELALH DELFTQLAAR 600
LPEDLPLTRT AIERRMAA 618
Length:618
Mass (Da):67,985
Last modified:October 1, 2003 - v1
Checksum:i7E073BF41021D83E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640427 Genomic DNA. Translation: CAE36670.1.
RefSeqiNP_883669.1. NC_002928.3.
WP_010928001.1. NC_002928.3.

Genome annotation databases

EnsemblBacteriaiCAE36670; CAE36670; BPP1368.
GeneIDi1667808.
KEGGibpa:BPP1368.
PATRICi21146423. VBIBorPar43418_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX640427 Genomic DNA. Translation: CAE36670.1 .
RefSeqi NP_883669.1. NC_002928.3.
WP_010928001.1. NC_002928.3.

3D structure databases

ProteinModelPortali Q7WAK8.
SMRi Q7WAK8. Positions 17-617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257311.BPP1368.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAE36670 ; CAE36670 ; BPP1368 .
GeneIDi 1667808.
KEGGi bpa:BPP1368.
PATRICi 21146423. VBIBorPar43418_1422.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci BPAR257311:BPP1368-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Entry informationi

Entry nameiPCKG_BORPA
AccessioniPrimary (citable) accession number: Q7WAK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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