Reviewed, UniProtKB/Swiss-Prot Q7WAE4 (ARLY_BORPA)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BPP1433

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137743

Sequences

	Sequence		Length	Mass (Da)
	Q7WAE4-1 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: CCDD15FE3F1DFA70	FASTA	473	52,004
	10 20 30 40 50 60 MANTSHSSQD QFANKAQAWS ARFSEPVSDL VKRYTASVDF DKRMARHDIR GSLAHADMLA 70 80 90 100 110 120 AQGIISAQDL ADIQRGMQQI LSEIDAGSFQ WLLDLEDVHL NIEKRLVELV GDAGKRLHTG 130 140 150 160 170 180 RSRNDQVATD IRLWLRDEID TLVDLLRQLR HALATVALEN AATIMPGFTH LQVAQPVTFG 190 200 210 220 230 240 HHLLAYAEMF GRDAERLADC RRRVNRLPLG AAALAGTSYP IDRERVARTL GFDGVCRNSL 250 260 270 280 290 300 DAVSDRDFGI EFCAAGALIM THISRLSEEL VLWMSPRVGF IDLADRFCTG SSIMPQKKNP 310 320 330 340 350 360 DVPELARGKT GRVNGHLVAL LTLMKGQPLA YNKDNQEDKE GLFDTADTLR DTLTIFADMA 370 380 390 400 410 420 GGIKVKADNM RAAALQGFAT ATDLADYLVK RGLPFRDAHE IVAHAVRDCE QRGCDLADLS 430 440 450 460 470 LADLQAYHPS IGEDIHQVLT LEGSVAARKH IGGTAPERVR EEAQRVLAET AGA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640427 Genomic DNA. Translation: CAE36735.1. Different initiation.
RefSeq	NP_883733.1.
3D structure databases
SMR	Q7WAE4. Positions 29-465.
ModBase	Search...
Genome annotation databases
GeneID	1665341.
KEGG	bpa:BPP1433.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
PhylomeDB	Q7WAE4.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP1433-MONOMER.
BRENDA	4.3.2.1. 263123.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BORPA

Accession

Primary (citable) accession number: Q7WAE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2004
Last modified:	February 9, 2010
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)