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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotation

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciBPAR257311:BPP1463-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:BPP1463Imported
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)Imported
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001421 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7WAB6.
SMRiQ7WAB6. Positions 4-83, 116-193, 302-540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 2 lipoyl-binding domains.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7WAB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIVEIKVP DIGDFKEVEV IEVLVSAGDT IKAEQSLITV ESDKASMEIP
60 70 80 90 100
ASAAGVVKSV KVKVGDKIAE GTVILEVEAA GEAAAAPKAE QAPEAAEAPK
110 120 130 140 150
ADAAKAEAPA AAGPIEVKVP DIGDFKEVEV IEVLVAEGDT IKAEQSLITV
160 170 180 190 200
ESDKASMEIP ASAGGVVQSL KVKVGDKVAM GTVIAVVQGQ GAAAPAAKAE
210 220 230 240 250
APAAAEPAAS ASASAPAPAQ RPAPAAALQD EDLKPGQLPH ASPSVRKFAR
260 270 280 290 300
ELGVNLSRVT GSAAKGRITA DDVRAYVKQA LSAGAPAGAS GGGDGAALGL
310 320 330 340 350
LPWPKIDFTK FGPIEAKPLS RIKKISGANL HRNWVMIPHV TNNDEADITD
360 370 380 390 400
LEALRVALNK ENEKSGVKVT MLAFLIKAVV AALKKFPEFN ASLDGDNLVL
410 420 430 440 450
KQYYHIGFAA DTPNGLVVPV VRDADKKGIL ELARETSELA RKAREGKVSP
460 470 480 490 500
AEMQGGCFSI SSLGGIGGTH FTPIINAPEV AILGVSRSAH KPVWDGKQFV
510 520 530 540
PRLTLPLSLS YDHRVIDGAS AARFNAYLGQ LLADFRRIAL
Length:540
Mass (Da):55,912
Last modified:October 1, 2003 - v1
Checksum:i8266657E32C4D3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640427 Genomic DNA. Translation: CAE36765.1.
RefSeqiNP_883761.1. NC_002928.3.
WP_010928050.1. NC_002928.3.

Genome annotation databases

EnsemblBacteriaiCAE36765; CAE36765; BPP1463.
KEGGibpa:BPP1463.
PATRICi21146623. VBIBorPar43418_1521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640427 Genomic DNA. Translation: CAE36765.1.
RefSeqiNP_883761.1. NC_002928.3.
WP_010928050.1. NC_002928.3.

3D structure databases

ProteinModelPortaliQ7WAB6.
SMRiQ7WAB6. Positions 4-83, 116-193, 302-540.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE36765; CAE36765; BPP1463.
KEGGibpa:BPP1463.
PATRICi21146623. VBIBorPar43418_1521.

Phylogenomic databases

HOGENOMiHOG000281562.
KOiK00627.
OMAiTEIMVAV.

Enzyme and pathway databases

BioCyciBPAR257311:BPP1463-MONOMER.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
    Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N., Harris D.E., Holden M.T., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.M., Temple L., James K., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
    , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
    Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12822 / ATCC BAA-587 / NCTC 13253Imported.

Entry informationi

Entry nameiQ7WAB6_BORPA
AccessioniPrimary (citable) accession number: Q7WAB6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.