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Q7WAB6

- Q7WAB6_BORPA

UniProt

Q7WAB6 - Q7WAB6_BORPA

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciBPAR257311:BPP1463-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Name:aceFImported
    Ordered Locus Names:BPP1463Imported
    OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)Imported
    Taxonomic identifieri257311 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001421: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi257311.BPP1463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7WAB6.
    SMRiQ7WAB6. Positions 4-83, 116-193, 302-540.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 2 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiTEIMVAV.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7WAB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNIVEIKVP DIGDFKEVEV IEVLVSAGDT IKAEQSLITV ESDKASMEIP    50
    ASAAGVVKSV KVKVGDKIAE GTVILEVEAA GEAAAAPKAE QAPEAAEAPK 100
    ADAAKAEAPA AAGPIEVKVP DIGDFKEVEV IEVLVAEGDT IKAEQSLITV 150
    ESDKASMEIP ASAGGVVQSL KVKVGDKVAM GTVIAVVQGQ GAAAPAAKAE 200
    APAAAEPAAS ASASAPAPAQ RPAPAAALQD EDLKPGQLPH ASPSVRKFAR 250
    ELGVNLSRVT GSAAKGRITA DDVRAYVKQA LSAGAPAGAS GGGDGAALGL 300
    LPWPKIDFTK FGPIEAKPLS RIKKISGANL HRNWVMIPHV TNNDEADITD 350
    LEALRVALNK ENEKSGVKVT MLAFLIKAVV AALKKFPEFN ASLDGDNLVL 400
    KQYYHIGFAA DTPNGLVVPV VRDADKKGIL ELARETSELA RKAREGKVSP 450
    AEMQGGCFSI SSLGGIGGTH FTPIINAPEV AILGVSRSAH KPVWDGKQFV 500
    PRLTLPLSLS YDHRVIDGAS AARFNAYLGQ LLADFRRIAL 540
    Length:540
    Mass (Da):55,912
    Last modified:October 1, 2003 - v1
    Checksum:i8266657E32C4D3D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640427 Genomic DNA. Translation: CAE36765.1.
    RefSeqiNP_883761.1. NC_002928.3.
    WP_010928050.1. NC_002928.3.

    Genome annotation databases

    EnsemblBacteriaiCAE36765; CAE36765; BPP1463.
    GeneIDi1665553.
    KEGGibpa:BPP1463.
    PATRICi21146623. VBIBorPar43418_1521.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX640427 Genomic DNA. Translation: CAE36765.1 .
    RefSeqi NP_883761.1. NC_002928.3.
    WP_010928050.1. NC_002928.3.

    3D structure databases

    ProteinModelPortali Q7WAB6.
    SMRi Q7WAB6. Positions 4-83, 116-193, 302-540.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257311.BPP1463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE36765 ; CAE36765 ; BPP1463 .
    GeneIDi 1665553.
    KEGGi bpa:BPP1463.
    PATRICi 21146623. VBIBorPar43418_1521.

    Phylogenomic databases

    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi TEIMVAV.

    Enzyme and pathway databases

    BioCyci BPAR257311:BPP1463-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 2 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 2 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 2 hits.
    PS00189. LIPOYL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 12822 / ATCC BAA-587 / NCTC 13253Imported.

    Entry informationi

    Entry nameiQ7WAB6_BORPA
    AccessioniPrimary (citable) accession number: Q7WAB6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3