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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

aceF

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandPyruvateImported

Enzyme and pathway databases

BioCyciBPAR257311:G1GSY-1503-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
Name:aceFImported
Ordered Locus Names:BPP1463Imported
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)Imported
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001421 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7WAB6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 78Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini114 – 188Lipoyl-bindingInterPro annotationAdd BLAST75
Domaini240 – 277Peripheral subunit-binding (PSBD)InterPro annotationAdd BLAST38

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000281562
KOiK00627
OMAiTMEFESF

Family and domain databases

Gene3Di3.30.559.10, 1 hit
4.10.320.10, 1 hit
InterProiView protein in InterPro
IPR003016 2-oxoA_DH_lipoyl-BS
IPR001078 2-oxoacid_DH_actylTfrase
IPR006256 AcTrfase_Pyrv_DH_cplx
IPR000089 Biotin_lipoyl
IPR023213 CAT-like_dom_sf
IPR036625 E3-bd_dom_sf
IPR004167 PSBD
IPR011053 Single_hybrid_motif
PANTHERiPTHR43178:SF2 PTHR43178:SF2, 3 hits
PfamiView protein in Pfam
PF00198 2-oxoacid_dh, 1 hit
PF00364 Biotin_lipoyl, 2 hits
PF02817 E3_binding, 1 hit
SUPFAMiSSF47005 SSF47005, 1 hit
SSF51230 SSF51230, 2 hits
TIGRFAMsiTIGR01348 PDHac_trf_long, 1 hit
PROSITEiView protein in PROSITE
PS50968 BIOTINYL_LIPOYL, 2 hits
PS00189 LIPOYL, 2 hits
PS51826 PSBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q7WAB6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIVEIKVP DIGDFKEVEV IEVLVSAGDT IKAEQSLITV ESDKASMEIP
60 70 80 90 100
ASAAGVVKSV KVKVGDKIAE GTVILEVEAA GEAAAAPKAE QAPEAAEAPK
110 120 130 140 150
ADAAKAEAPA AAGPIEVKVP DIGDFKEVEV IEVLVAEGDT IKAEQSLITV
160 170 180 190 200
ESDKASMEIP ASAGGVVQSL KVKVGDKVAM GTVIAVVQGQ GAAAPAAKAE
210 220 230 240 250
APAAAEPAAS ASASAPAPAQ RPAPAAALQD EDLKPGQLPH ASPSVRKFAR
260 270 280 290 300
ELGVNLSRVT GSAAKGRITA DDVRAYVKQA LSAGAPAGAS GGGDGAALGL
310 320 330 340 350
LPWPKIDFTK FGPIEAKPLS RIKKISGANL HRNWVMIPHV TNNDEADITD
360 370 380 390 400
LEALRVALNK ENEKSGVKVT MLAFLIKAVV AALKKFPEFN ASLDGDNLVL
410 420 430 440 450
KQYYHIGFAA DTPNGLVVPV VRDADKKGIL ELARETSELA RKAREGKVSP
460 470 480 490 500
AEMQGGCFSI SSLGGIGGTH FTPIINAPEV AILGVSRSAH KPVWDGKQFV
510 520 530 540
PRLTLPLSLS YDHRVIDGAS AARFNAYLGQ LLADFRRIAL
Length:540
Mass (Da):55,912
Last modified:October 1, 2003 - v1
Checksum:i8266657E32C4D3D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640427 Genomic DNA Translation: CAE36765.1
RefSeqiWP_010928050.1, NC_002928.3

Genome annotation databases

EnsemblBacteriaiCAE36765; CAE36765; BPP1463
KEGGibpa:BPP1463

Similar proteinsi

Entry informationi

Entry nameiQ7WAB6_BORPA
AccessioniPrimary (citable) accession number: Q7WAB6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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