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Q7WAB6 (Q7WAB6_BORPA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyltransferase component of pyruvate dehydrogenase complex RuleBase RU361137

EC=2.3.1.12 RuleBase RU361137
Gene names
Name:aceF EMBL CAE36765.1
Ordered Locus Names:BPP1463 EMBL CAE36765.1
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity. RuleBase RU361137

Catalytic activity

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine. RuleBase RU361137

Cofactor

Binds 1 lipoyl cofactor covalently By similarity. RuleBase RU361137

Binds 2 lipoyl cofactors covalently By similarity. RuleBase RU361137

Binds 3 lipoyl cofactors covalently By similarity. RuleBase RU361137

Subunit structure

Forms a 24-polypeptide structural core with octahedral symmetry By similarity. RuleBase RU361137

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU361137

Contains 2 lipoyl-binding domains. RuleBase RU361137

Ontologies

Sequences

Sequence LengthMass (Da)Tools
Q7WAB6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8266657E32C4D3D9

FASTA54055,912
        10         20         30         40         50         60 
MSNIVEIKVP DIGDFKEVEV IEVLVSAGDT IKAEQSLITV ESDKASMEIP ASAAGVVKSV 

        70         80         90        100        110        120 
KVKVGDKIAE GTVILEVEAA GEAAAAPKAE QAPEAAEAPK ADAAKAEAPA AAGPIEVKVP 

       130        140        150        160        170        180 
DIGDFKEVEV IEVLVAEGDT IKAEQSLITV ESDKASMEIP ASAGGVVQSL KVKVGDKVAM 

       190        200        210        220        230        240 
GTVIAVVQGQ GAAAPAAKAE APAAAEPAAS ASASAPAPAQ RPAPAAALQD EDLKPGQLPH 

       250        260        270        280        290        300 
ASPSVRKFAR ELGVNLSRVT GSAAKGRITA DDVRAYVKQA LSAGAPAGAS GGGDGAALGL 

       310        320        330        340        350        360 
LPWPKIDFTK FGPIEAKPLS RIKKISGANL HRNWVMIPHV TNNDEADITD LEALRVALNK 

       370        380        390        400        410        420 
ENEKSGVKVT MLAFLIKAVV AALKKFPEFN ASLDGDNLVL KQYYHIGFAA DTPNGLVVPV 

       430        440        450        460        470        480 
VRDADKKGIL ELARETSELA RKAREGKVSP AEMQGGCFSI SSLGGIGGTH FTPIINAPEV 

       490        500        510        520        530        540 
AILGVSRSAH KPVWDGKQFV PRLTLPLSLS YDHRVIDGAS AARFNAYLGQ LLADFRRIAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640427 Genomic DNA. Translation: CAE36765.1.
RefSeqNP_883761.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7WAB6.
SMRQ7WAB6. Positions 4-83, 116-193, 302-540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP1463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE36765; CAE36765; BPP1463.
GeneID1665553.
KEGGbpa:BPP1463.
PATRIC21146623. VBIBorPar43418_1521.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000281562.
KOK00627.
OMATEIMVAV.

Enzyme and pathway databases

BioCycBPAR257311:BPP1463-MONOMER.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR006256. AcTrfase_Pyrv_DH_cplx.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 2 hits.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 2 hits.
TIGRFAMsTIGR01348. PDHac_trf_long. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 2 hits.
PS00189. LIPOYL. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ7WAB6_BORPA
AccessionPrimary (citable) accession number: Q7WAB6
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)