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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi416 – 423ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:BPP1718
OrganismiBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
Taxonomic identifieri257311 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001421 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 86HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei190 – 210HelicalUniRule annotationAdd BLAST21
Transmembranei290 – 310HelicalUniRule annotationAdd BLAST21
Transmembranei317 – 337HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925691 – 623Lipid A export ATP-binding/permease protein MsbAAdd BLAST623

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7W9N7.
SMRiQ7W9N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 349ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini382 – 618ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiSPLMEFL.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7W9N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAWRPGRPD GCRAAGGRRY NPGHDCIKAS VSLNSAARNA PAGSQPVKAE
60 70 80 90 100
LWKRVYSRVG SYWKGLVLAV LLMAGAAATQ PTLAVIMKPL LDDGFSGAKP
110 120 130 140 150
HYVWFLPLAV VGLILLRGIC NFFSDYLLAW VANNVLRGIR GEMFERLLGL
160 170 180 190 200
PDADFKRGDT GRLLNRFTID AGNVTGYATD VITVLVRETL VVIALIGVLL
210 220 230 240 250
YMSWALTLII LVMLPVSVGI ARAFTRRLRR INRETVNMNA ELTRVVSEGI
260 270 280 290 300
DGQRVIKLFD GYDAERRRFD FVNSRLRRFA MRSATADAAL TPLTQVCISV
310 320 330 340 350
AVGAVIAVAL SQANSGALTV GSFASFMAAL AQIFDPIKRL TNLAGKMQKM
360 370 380 390 400
LVAAESVFTL VDQTPEADAG TRALPEPVRG KVEFRAVSHR FPDADRDTVS
410 420 430 440 450
AVSFLVEPGQ TVALVGRSGS GKTTLVNMLP RFVLPDGGDI LFDDVPIQDL
460 470 480 490 500
TLRSLRSHLS LVSQDVVLFD DTIAANVGYG AGGTVDDARV RDALAAANLL
510 520 530 540 550
EFVDGLPLGI HTPVGQNAAR LSGGQRQRLA IARALIKNAP VLILDEATSA
560 570 580 590 600
LDNESERQVQ ASLERLMRGR TTLVIAHRLS TVQNADRIIV LDAGKIVEHG
610 620
PHSELLAANG LYASLYNMQF RED
Length:623
Mass (Da):67,415
Last modified:October 1, 2003 - v1
Checksum:i2B63F12C3FA612E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX640428 Genomic DNA. Translation: CAE37019.1.

Genome annotation databases

EnsemblBacteriaiCAE37019; CAE37019; BPP1718.
KEGGibpa:BPP1718.

Similar proteinsi

Entry informationi

Entry nameiMSBA_BORPA
AccessioniPrimary (citable) accession number: Q7W9N7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families