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Q7W9J1 (QUEF_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADPH-dependent 7-cyano-7-deazaguanine reductase
EC=1.7.1.13
Alternative name(s):
7-cyano-7-carbaguanine reductase
NADPH-dependent nitrile oxidoreductase
PreQ(0) reductase
Gene names
Name:queF
Ordered Locus Names:BPP1768
OrganismBordetella parapertussis [Complete proteome] [HAMAP]
Taxonomic identifier519 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) By similarity. HAMAP MF_00817

Catalytic activity

7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-carbaguanine + 2 NADPH. HAMAP MF_00817

Pathway

tRNA modification; tRNA-queuosine biosynthesis. HAMAP MF_00817

Subcellular location

Cytoplasm Probable HAMAP MF_00817.

Sequence similarities

Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionoxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

preQ1 synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273NADPH-dependent 7-cyano-7-deazaguanine reductase HAMAP MF_00817
PRO_0000163021

Sequences

Sequence LengthMass (Da)Tools
Q7W9J1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 45283F723442B038

FASTA27330,650
        10         20         30         40         50         60 
MSLSNAPLGQ HVAYPSQYDP GLLFPIPRAT NRASLQLGAT LPFTGVDLWN AYELSWLDAR 

        70         80         90        100        110        120 
GKPRVAMATF SFPADSPNIV ESKSFKLYLN SFNQTRLPNA QALRDRLERD LAAAAGAPVG 

       130        140        150        160        170        180 
LKFISPQRFG ELNMAELDGI YIDKLDIEID TYEPAPQLLQ CAPGDEVEET LATRLLKSNC 

       190        200        210        220        230        240 
PVTGQPDWAS LQVRYRGRPI DRAALLKYVV SFRQHAEFHE HCVERIFGDI MRACQPRQLT 

       250        260        270 
VYARYTRRGG LDINPWRSNF ESAPPADVRT ARQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX640428 Genomic DNA. Translation: CAE37069.1.
RefSeqNP_884039.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W9J1.
SMRQ7W9J1. Positions 14-273.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1667909.
GenomeReviewsGene locus BPP1768 in contig BX470249_GR.
KEGGbpa:BPP1768.
NMPDRfig|257311.1.peg.1673.
PATRIC21147306. VBIBorPar43418_1855.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289139.
OMACVERIFC.
PhylomeDBQ7W9J1.
ProtClustDBPRK11792.

Enzyme and pathway databases

BioCycBPAR257311:BPP1768-MONOMER.

Family and domain databases

HAMAPMF_00817. QueF_type2.
[Tree]
InterProIPR016428. CN_OxRdtase_NADPH-dep_YqcD.
IPR020602. GTP_CycHdrlase_I/CN_OxRdtase.
[Graphical view]
KOK06879.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
PIRSFPIRSF004750. Nitrile_oxidored_YqcD_prd. 1 hit.
TIGRFAMsTIGR03138. QueF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUEF_BORPA
AccessionPrimary (citable) accession number: Q7W9J1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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