Q7W950 (AROC_BORPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	BPP1923

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Chorismate synthase HAMAP MF_00300		PRO_0000140558

Sequences

	Sequence		Length	Mass (Da)
	Q7W950 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9A67A10966C5AA40	FASTA	353	37,216
	10 20 30 40 50 60 MSGNTLGTLF CVTNFGESHG PAIGCVVDGC PPGLPLEAAD IQAELDRRRP GTSRHVTQRQ 70 80 90 100 110 120 EADQVEILSG VYEGVTTGTP IGLLIRNTDA RSKDYSNIAD TFRPGHADFA YWRKYGVRDP 130 140 150 160 170 180 RGGGRSSARL TAPTVAAGAI AKKWLAGQFG VRVRGYMSQL GPIAIPFSSW DDVPGNAFYA 190 200 210 220 230 240 PNAAVVPELE AYMDQLRRDG DSVGARIEVV AEGLPAGWGE PIYDRLDADI AHAMMGLNAV 250 260 270 280 290 300 KGVSLGAGFE SIAQRGSEHG GEITPEGFAS NHAGGVLGGI STGQPITVSL AIKPTSSIRV 310 320 330 340 350 ERRSVNRAGE PVMVQTLGRH DPCVGIRATP IAEALLALVL IDHALRQRAQ CGG

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640428 Genomic DNA. Translation: CAE37223.1.
RefSeq	NP_884184.1. NC_002928.3.
3D structure databases
ProteinModelPortal	Q7W950.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1664876.
GenomeReviews	Gene locus BPP1923 in contig BX470249_GR.
KEGG	bpa:BPP1923.
NMPDR	fig|257311.1.peg.1818.
PATRIC	21147654. VBIBorPar43418_2026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
PhylomeDB	Q7W950.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP1923-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_BORPA

Accession

Primary (citable) accession number: Q7W950

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program