ID   Q7W895_BORPA            Unreviewed;       673 AA.
AC   Q7W895;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   SubName: Full=Regulator {ECO:0000313|EMBL:CAE37545.1};
GN   OrderedLocusNames=BPP2245 {ECO:0000313|EMBL:CAE37545.1};
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311 {ECO:0000313|EMBL:CAE37545.1, ECO:0000313|Proteomes:UP000001421};
RN   [1] {ECO:0000313|Proteomes:UP000001421}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253
RC   {ECO:0000313|Proteomes:UP000001421};
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; BX640429; CAE37545.1; -; Genomic_DNA.
DR   RefSeq; WP_010928442.1; NC_002928.3.
DR   AlphaFoldDB; Q7W895; -.
DR   GeneID; 69421629; -.
DR   KEGG; bpa:BPP2245; -.
DR   HOGENOM; CLU_020306_1_0_4; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd18774; PDC2_HK_sensor; 2.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR004010; Double_Cache_2.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   InterPro; IPR033480; sCache_2.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF08269; dCache_2; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM01049; Cache_2; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF81606; PP2C-like; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        340..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          359..420
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
SQ   SEQUENCE   673 AA;  73951 MW;  C509C859FAAC7430 CRC64;
     MFMRRTPRLE LPLSLRGKFL LLIASTLLLV GIVVMLVTQR DVTNNIIKNE LHAVSNIMDL
     VVRDTDTRWS TLLDDKIRTI RESRRQLIQL SAVVISVLNA YAAQAERGHV TTGAAKGMAR
     VWLNHLDLGP RRVAFAYDAE GTVLASTNPR MIDRDLSGIR DFKGRPLAAA MYEESRNGGR
     GFAIYPSPLD ESAQMRHAYF VYFPAWKWVL AISDSSQAII DKVAAQKANM IAAIDRNLSE
     LRLSRHGFVF VVADDGTVIV PPPPSAARLL DSTDVESGRV LHTMLAEISS TRGLTLRFTN
     GESAWQIDAL RYKPLHWTII GVVPEPDLTD PAQNLARRQA LIFAATLLAG LMLAWVVAVR
     IARPLAQLSN YARQLPNQDL TEPIRVPPSV ACLPRRRRDE VGQLAESFLF MNEQLHHNVR
     ALMAQISNRE RLESELSIAR SIQLGLLPQP LSDAATRGSQ LRAVMYPARE VGGDFYDYFV
     LADGRLCFAI GDVSGKGVPA ALFMAIVRTL IRSVAEEEHD PGAIATKVNH RLVENNPKLM
     FVTLLIGVFT PETGALTWVN AGHPPPLLID ERGEVRLLQG SSGAACGVLD NEAYSTLSTT
     LPNGTSLVAF TDGVTEAIHG GCAQYGLPRL VALMQGAPRA AAELIEHILH DLREFAADSE
     QSDDLTIIAI HRP
//