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Q7W850 (ASPD2_BORPA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase 2

EC=1.4.1.21
Gene names
Name:nadX2
Ordered Locus Names:BPP2295
OrganismBordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) [Complete proteome] [HAMAP]
Taxonomic identifier257311 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length267 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP-Rule MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP-Rule MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP-Rule MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity.

Sequence similarities

Belongs to the L-aspartate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 267267Probable L-aspartate dehydrogenase 2 HAMAP-Rule MF_01265
PRO_0000144884

Sites

Active site2191 By similarity
Binding site1231NAD; via amide nitrogen By similarity
Binding site1891NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7W850 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: F893BCE262E4F60E

FASTA26727,782
        10         20         30         40         50         60 
MTHRIAFIGL GAIASDVAAG LLADAAQPCQ LAALTRNAAD LPPALAGRVA LLDGLPGLLA 

        70         80         90        100        110        120 
WRPDLVVEAA GQQAIAEHAE GCLKAGLDMI ICSAGALADD ALRARLIAAA EAGGARIRVP 

       130        140        150        160        170        180 
AGAIAGLDYL QAVAGRDDAE VVYESRKPVA AWRAELPGMG IDPDTLAESR TLFSGPAREA 

       190        200        210        220        230        240 
ALRFPKNLNV AATLALAGIG MTRTRVEVVV DPRARGNQHR IQVRSPLGEM QIELVNAPSP 

       250        260 
ANPKTSWLVA QSVLATIRRH LARFTIG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX640430 Genomic DNA. Translation: CAE37593.1.
RefSeqNP_884541.1. NC_002928.3.

3D structure databases

ProteinModelPortalQ7W850.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257311.BPP2295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE37593; CAE37593; BPP2295.
GeneID1664742.
KEGGbpa:BPP2295.
PATRIC21148440. VBIBorPar43418_2412.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1712.
HOGENOMHOG000206326.
KOK06989.
OMALARFTIG.
OrthoDBEOG6ND0JC.
ProtClustDBPRK13301.

Enzyme and pathway databases

BioCycBPAR257311:BPP2295-MONOMER.
UniPathwayUPA00253; UER00456.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01265. NadX.
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameASPD2_BORPA
AccessionPrimary (citable) accession number: Q7W850
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways