Q7W7Q0 (DXS_BORPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BPP2464

Organism

Bordetella parapertussis [Complete proteome] [HAMAP]

Taxonomic identifier

519 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000189089

Sequences

	Sequence		Length	Mass (Da)
	Q7W7Q0 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 5D023E312C76D694	FASTA	620	66,231
	10 20 30 40 50 60 MTTELLDRIL SPADLRQLDR RELKRLADEL RGFVLESVSR TGGHLSSNLG TVELSLALHY 70 80 90 100 110 120 VFDTPHDRIV WDVGHQSYPH KILTGRREGM AHLRQQGGIS GFPKRSESEY DAFGTAHSST 130 140 150 160 170 180 SISAALGMAV ASRNAGVQRQ HIAVIGDGAM SAGMAFEAMN NAGVTPNINL LVVLNDNDMS 190 200 210 220 230 240 ISPPVGALNR YLARLMSGQF YAAAKNVGRA VLQHVPPVLE LARRLEEHAK GMVTPATLFE 250 260 270 280 290 300 EFGFNYVGPI DGHDLDALVP TLQNLRALPG LQFLHVVTRK GQGYKLAEAD PVLYHGPGKF 310 320 330 340 350 360 DPAVGIQQAK APARKTFTQV FGQWLCDMAE RDERLVGITP AMREGSGLVE FEQRFPQRYF 370 380 390 400 410 420 DVGIAEQHAV TFAAGLACEG QKPVVAIYST FLQRGYDQLV HDVALQNLDV TFALDRAGLV 430 440 450 460 470 480 GADGATHAGN YDIAFLRCVP NMVVAAPSDE SEARLLLSTC YEHPGPASVR YPRGAGCGAA 490 500 510 520 530 540 VGEGLATVPL GKGLVRREGR RIAILGFGTL VQAALGAAGQ IDATVADMRF VKPLDRELVL 550 560 570 580 590 600 ELAARHDALV TVEEAAIMGG AGSAVLETLA EAGVTLPVLQ LGLPDAFIDH GDQAALLAGL 610 620 GLDAAGIERA IRARFGALLA

References

[1]

"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed: 12910271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 12822 / ATCC BAA-587 / NCTC 13253.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX640430 Genomic DNA. Translation: CAE37759.1.
RefSeq	NP_884695.1. NC_002928.3.
3D structure databases
ProteinModelPortal	Q7W7Q0.
SMR	Q7W7Q0. Positions 3-613.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1664855.
GenomeReviews	Gene locus BPP2464 in contig BX470249_GR.
KEGG	bpa:BPP2464.
PATRIC	21148807. VBIBorPar43418_2588.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	DPILYHG.
PhylomeDB	Q7W7Q0.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	BPAR257311:BPP2464-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR001017. DH_E1. IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BORPA

Accession

Primary (citable) accession number: Q7W7Q0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program